How is pharmacovigilance done?

Pharmacovigilance actually has a special term called pharmacovigilance

Pharmacovigilance can detect risks earlier

For example, the drug rofecoxib was found to have serious cardiovascular adverse reactions after 5 years of listing, and it was eventually withdrawn from the market.

Sentinel Program for Drug Surveillance in the United States

In 2008, the US FDA launched the Sentinel Program

The US FDA's sentinel mode can monitor the risk of drugs throughout the entire life cycle of drugs, automatically classify their risk levels, and automatically identify safety issues

It is extremely difficult to determine the relationship between adverse events and drugs

A variety of adverse events will occur in clinical practice, including vomiting, diarrhea, fever and palpitations

summary

The focus of pharmacovigilance is on active discovery, which is based on high-level data mining and automated analysis systems

Combining multiple data sources for pharmacovigilance has great research potential