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Cancer is the second most deadly disease in the world, killing more than 10 million people every year.
Cisplatin (CDDP) is a chemotherapy drug used to treat a variety of cancers, such as lung cancer, brain tumors, breast cancer , liver cancer , etc.
Breast cancer
Studies have shown that high-dose CDDP is not only ineffective in destroying tumor cells, but also has adverse side effects, and may even lead to sudden death of patients.
Recently, researchers from Niigata University in Japan reported a study on the monitoring of CDDP levels in liver cancer cells, which brought a glimmer of hope for controlling the dosage of chemotherapy drugs.
org/10.
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Stomach cancer
The expression of APM2 in various organizations.
The expression of APM2 in various organizations.
Effect of APM2 expression in HCC cells on CDDP sensitivity
Effect of APM2 expression in HCC cells on CDDP sensitivityExpression of ERCC6L in HCC cell line overexpressing ACC2
Expression of ERCC6L in HCC cell line overexpressing ACC2By evaluating the level of serum APM2 and its chemical sensitivity to CDDP, the cutoff value of serum APM2 for predicting CDDP sensitivity was determined to be 18.
Serum APM2 concentration and chemosensitivity to CDDP in patients with liver cancer or gastric cancer
Serum APM2 concentration and chemosensitivity to CDDP in patients with liver cancer or gastric cancerThese results indicate that the expression of APM2 is related to CDDP sensitivity, and serum APM2 can be used as an effective biomarker for HCC and GC to determine the sensitivity to CDDP.
The research paved the way for effective monitoring of chemotherapy drug levels and safe medication.
Undoubtedly, under the background that researchers all over the world are working hard to develop new methods to optimize and control the serious side effects caused by the concentration of chemotherapeutic drugs, such research results are crucial.
The researchers said that this is the first report to prove that the level of APM2 in serum can predict the chemical sensitivity of CDDP.
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