How to improve the recovery rate of hot reflux extraction concentration unit?

[technical article of China Pharmaceutical network] compared with the traditional concentration process, the hot reflux extraction and concentration process has strong adaptability, high paste collection rate, short extraction time, and lower temperature than the traditional concentration process, which saves the solvent to a certain extent, has a high degree of automation, requires less labor cost, and is widely favored by the market According to the industry, in the working process of hot reflux extraction and concentration, cream collection is a crucial link The determination of the recovery rate is very important for the extraction of drugs and new products, which is directly related to the selection of future dosage forms and the determination of preparation technology Among them, in the field of traditional Chinese medicine, paste collection rate is an important production management index in the pharmaceutical industry of Chinese patent medicine, which is directly related to the quality and cost of products The higher the recovery rate of traditional Chinese medicine is, the more complete the extraction of the drug is, and the components of the drug are relatively pure to a certain extent Therefore, traditional Chinese medicine manufacturers and manufacturers attach great importance to the drug cream rate So, for manufacturing enterprises, how to improve the paste collection rate of the hot reflux extraction and concentration process system? Experts introduced that the recovery rate is mainly calculated by dividing the amount of ointment by the amount of medicinal materials It generally refers to the recovery rate of dry ointment During the determination, 25ml of the constant volume solution can be absorbed After the solution is dried, it can be put into the weighing evaporation dish for vacuum drying until it reaches the constant weight state The formula for calculating the paste collection rate is as follows: paste collection rate (%) = (weighed dry paste weight x dilution multiple / medicine weight) X100% The main way to improve the recovery rate is to pay attention to the appropriate amount of solvent in the hot reflux shrinkage extraction process, to improve the extraction time within a certain range, and to increase the extraction times reasonably Pay attention to the material selection The technical personnel in the industry said that, first of all, more attention must be paid to the material selection in order to improve the paste collection rate, and the size of the material particle size and the size of the hot reflux extraction and concentration equipment should be well controlled In addition, some materials are difficult to concentrate For example, no matter how to improve the technology, it is impossible to improve the recovery rate of some medicinal materials with less powder Pay attention to the feeding sequence In the process of receiving paste, the feeding sequence is very important It must be accurate to ensure the success of receiving paste Reasonable planning of extraction process parameters extraction process parameters affect the effect and success rate of drug paste collection, including soaking time, heating time, holding time, intermediate mixing or circulation time In the process of concentration, the effect of membrane concentration is more ideal than that of traditional Chinese medicine Membrane concentration mainly adopts the combination of ultrafiltration and reverse osmosis, and then uses high-speed centrifugal dryer to remove water from the extract In the process of drying the liquid extract into dry extract, attention should be paid to avoid the loss of the liquid extract and unnecessary loss In conclusion, to improve the recovery rate of drugs, it is necessary to control the size of the materials and the size of the particles, ensure the accuracy of the feeding sequence, and reasonably plan the extraction process parameters The industry reminds that if the paste receiving rate can not be improved all the time, it is necessary to consider the conversion process or reformulate the formula It is reported that due to the late start of the research on the extraction and concentration process in China, the experience in the extraction and concentration of animals, plants and other drugs is not mature enough, and the hot reflux extraction and concentration process system is currently a relatively common method for the extraction and concentration work As an important index in this system, the paste collection rate must be improved At the same time, it is necessary to pay attention to the principle of appropriate amount to control the paste collection rate within a reasonable range.