How to realize scientific and technological innovation and industrial upgrading of traditional Chinese Medicine

[opinions of experts from chinapharma Com 】In the outline of strategic planning for the development of traditional Chinese medicine (2016-2030), the development of traditional Chinese medicine has been upgraded to a national strategy It is proposed that efforts should be made to promote the innovation of traditional Chinese medicine, deepen the basic theory of traditional Chinese medicine, research on syndrome differentiation and treatment methods, promote the creation of major new drugs, and promote the industrialization of innovation achievements By 2020, the total output value of traditional Chinese medicine industry will account for more than 30% of the total output value of the pharmaceutical industry, and the industry of traditional Chinese medicine will become a national economy One of the important pillars The 13th five year plan for the development of traditional Chinese medicine and several opinions on speeding up the construction of scientific and technological innovation system of traditional Chinese medicine all set clear goals for accelerating the deep integration of industry and technology and strengthening the industrial cluster of traditional Chinese medicine, which will greatly promote the overall improvement of scientific and technological innovation capacity of traditional Chinese medicine and support the development of traditional Chinese medicine However, at present, the scientific and technological innovation system and capacity-building of traditional Chinese medicine are still insufficient, and the development of each region and industrial chain is unbalanced, which restricts the healthy and sustainable development of traditional Chinese medicine industry In order to promote the industrial transformation and upgrading, and cultivate new economic growth momentum, the traditional Chinese medicine industry urgently needs the government to increase support, so as to further stimulate the original advantages of traditional Chinese medicine and improve the quality and efficiency of the industry On the afternoon of September 27, during the 2017 China (Macao) traditional medicine international cooperation forum, a hot discussion on how to achieve scientific and technological innovation and industrial upgrading of traditional Chinese medicine became the focus The forum was hosted by Professor Wang Yitao, Dean of the Chinese Medical Research Institute of the University of Macau The key to the research of traditional Chinese medicine lies in scientific research According to Professor Yu Qiang of Shanghai Pharmaceutical Research Institute, the key to the research of traditional Chinese medicine lies in scientific research and its effectiveness In fact, Chinese herbal medicine is effective What works is substance Professor Yu's conclusions include: cell model is an effective biological model for discovering the active components of Chinese herbal medicine; Chinese herbal medicine is rich in natural compounds that regulate immune signals; Chinese herbal medicine compounds have novel targets, sites and mechanisms of action; Chinese herbal medicine compounds generally have low concentration and activity, and are relatively safe; Chinese herbal medicine may be mainly through the regulation of immune system activity to treat diseases To internationalize, we need to let scientific research go out first Vice president Qin Wenjie of Beijing Zhendong Research Institute has solved the problem of whether traditional Chinese medicine is scientific To internationalize traditional Chinese medicine, we need to let scientific research go out Vice President Qin Wenjie said that the internationalization of traditional Chinese medicine has been going on for many years, but the effect is very small At present, only some countries recognize the legal status of traditional Chinese medicine, and most only recognize acupuncture, the real meaning of traditional Chinese medicine has not been recognized Up to now, none of the traditional Chinese medicine has been approved by the FDA as a drug The EU traditional medicine registration (single drug) can not represent traditional Chinese medicine, and there is no large-scale sales For many years, it has been very difficult for TCM to take the strategy of "products go out first" She believes that if TCM wants to go out, it should change its strategy and let scientific research go out first Let western medical scientists study, understand, identify, accept and like traditional Chinese medicine The enterprise cooperates with foreign institutions and experts to research TCM products; domestic and foreign medical institutions cooperate with experts to jointly cultivate talents (postdoctoral, visiting, advanced studies, etc.); domestic and foreign scientific research institutions cooperate to research TCM theory, mechanism, etc She stressed that only when scientific research goes out can talents, ideas and products go out with it Traditional Chinese medicine preparation: in order to be industrialized, Yang Yuhua, director of Gansu Modern Traditional Chinese medicine preparation engineering technology research center, has another identity as assistant to general manager of foci pharmaceutical She shares the same view with Professor Yu, but only uses science as the research direction of traditional Chinese medicine, and she uses standardization to meet the needs of industrialization She said that in nearly 90% of the traditional Chinese patent medicine product descriptions, adverse reactions, taboos and precautions are not clear How to make a westerner with different cultural background and no common sense of traditional Chinese medicine understand, accept and take it? It is very important to match the industrial policy with the market demand To this point, the rise path of Japanese Chinese medicine can be used for reference Housheng province has applied for legal protection for the quality standard and preparation process of 210 ancient prescriptions in Treatise on Febrile Diseases and miscellaneous diseases and synopsis of the golden chamber, which can be used without clinical trial Among them, 147 are approved as "medical drugs" which can be used in hospitals, and the remaining 63 are "general drugs" which are OTC drugs The Japanese people also highly approve of Chinese medicine, which grows at a rate of 15% every year Standardization is a prominent feature of modern production After standardization, the Chinese medicine did not conflict with the European and American standards, but was more conducive to the Chinese medicine out of Japan and accepted by the international market Chinese Herbal Pieces: not only to inherit, but also to innovate Cheng Jinle, chief engineer of Zhongshan Zhongzhi Pharmaceutical Group Chief engineer Cheng has been engaged in the research of traditional Chinese medicine broken wall decoction pieces for many years He understands that the modernization of traditional Chinese medicine is the process of combining the advantages and characteristics of traditional Chinese medicine with modern science and technology, interpreting, inheriting and carrying forward the theory and practice of traditional Chinese medicine, reforming and upgrading the modern research, development, production, management and application of traditional Chinese medicine, so as to meet the needs of social development The core elements of Cheng are inheritance and innovation In his opinion, the key issues of the modernization of Chinese herbal pieces should pay attention to the following three aspects: from the perspective of regulatory application, including: (1) poor uniformity and uniformity This is the root of the fundamental problems such as Chinese herbal pieces can not be standardized products and quality is not guaranteed If this problem is not solved, the modernization of traditional Chinese medicine is just an extravagant hope (2) great potential safety hazard Because of the change of environment and people's blind pursuit of output, the exogenous pollution of traditional Chinese medicine has become a serious hidden danger Pesticide residues, heavy metals, microbial pollution, sulfur dioxide, aflatoxin and so on have become new hot spots in the application of traditional Chinese medicine (3) the use of Chinese herbal pieces is not convenient It is too cumbersome and inconvenient to prepare and process the prescription of Chinese herbal pieces after clinical syndrome addition and subtraction into the appropriate dosage form, and the large amount of decoction has poor compliance, which is difficult to be accepted by the young generation, which is also one of the difficulties restricting the modern development and application of Chinese medicine From the perspective of applied basic research: (1) the material basis is not clear The understanding of the material basis of Chinese herbal pieces is incomplete (2) the effective ingredients are not clear Most of the active components are not well studied (3) the mechanism of modern pharmacodynamics is not clear Pharmacodynamics and safety need further study From the perspective of industrialization development: (1) the foundation of modern industry is weak The industrialization level of processing Chinese herbal pieces is not high (2) the standard problem is prominent The standardization level of Chinese herbal pieces is relatively low and the controllability is not high (3) resources are not guaranteed The sustainable development and utilization of traditional Chinese medicine resources are facing challenges Chinese herbal health food: adhere to the rationality of dosage and compatibility Professor Ye Zuguang mentioned that at present, there are many laws and regulations on the management of Chinese herbal medicine health food in China, among which the functional health food is defined as "special food", and the new registration management method proposes to implement the double track system of examination and approval system and record system, which aims at the vitamins, minerals, single flavor materials (traditional Chinese medicine, natural products, etc.), while the examination and approval system is aimed at imports Products, new food raw materials, compound products, traditional Chinese medicine compound With these management methods, it provides a very important guidance for the orderly development of Chinese herbal health food industry Ye Zuguang said that since the development of health food in China, it has become more and more popular Some big brands, such as Wang Laoji beverage, Jia Duobao, Yunnan Baiyao toothpaste, have become very successful cases in the market However, in the production process of health food, we still need to stick to the rationality of dosage and compatibility The rationality basis of formula composition includes traditional Chinese medicine and modern pharmacology, and the experimental data should not be ignored Varieties of Chinese herbal medicine: integration of production, learning and research can bring benefits Professor Tu Pengfei, Department of natural pharmacology, School of pharmacy, Peking University, has been devoted to systematic research and industrial promotion and application of Cistanche deserticola for many years He provided a successful case for the participants from the perspective of the integration of production, learning and research of traditional Chinese medicine varieties Cistanche deserticola, as a tonic Chinese medicine, is known as "desert ginseng", which is widely used in clinical prescription and health care products Professor Tu said that the industrialization of Cistanche deserticola has brought three benefits: first, economic benefits In the past three years, the direct economic benefits have increased output value by 1.509 billion yuan, profits and taxes by 696 million yuan, indirect economic benefits by 3.654 billion yuan, profits and taxes by 1.202 billion yuan; second, ecological benefits, creating a new model of sustainable desert with Chinese characteristics; third, social benefits, creating a new method of poverty alleviation in desert areas In addition, it has solved the resource of traditional Chinese medicine, guaranteed the supply of raw materials for clinical medicine and a large number of Chinese patent medicines and health care products, and promoted the development of traditional Chinese medicine and big health industry For the development prospect of Cistanche deserticola ecological industry, he made a ten-year plan to cultivate 50 billion large varieties of Chinese medicine, including 5 billion for ecological agriculture, 30 billion for green industry and 15 billion for featured commerce Original title: internationalization of traditional Chinese medicine, scientific research should be ahead of products Author: Chan Ping