Huazhong University of Science and Technology published a paper: A new mechanism for allosteric ligands to regulate the activity of Ɣaminobutyric acid type B receptors

On December 6, the internationally renowned journal eLife published an online publication titled "Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface" by Professor Liu Jianfeng’s team from the School of Life Science and Technology, Huazhong University of Science and Technology.

G protein-coupled receptors (GPCRs) are the largest cell membrane receptor protein family in the human body.

GABA _B receptor specific PAM can provide help for the temporal and spatial specific regulation of the physiological effects of natural ligand GABA .

Professor Liu Jianfeng’s research group continued the previous research results and systematically studied the functional properties of the three GABA _B receptor-specific PAMs in a variety of different combinations of chimeric receptors and a large number of mutant receptors using different functional experimental methods.

Figure: Schematic diagram of the molecular mechanism of GABA _B receptor activation and allosteric regulation

This work is another important discovery of Professor Liu Jianfeng's research group on the mechanism of GABAB receptor activation

Professor Liu Jianfeng’s research group has long been engaged in the research on the structure and function of the C group GPCR receptors.

Article link: https://elifesciences.