 Home > Biochemistry News > Biotechnology News > Hui Jingyi's group collaborated to reveal the dissociation and functional mechanism of MeCP2/Rbfox/LASR protein super-large complex in mice with Rett syndrome

Hui Jingyi's group collaborated to reveal the dissociation and functional mechanism of MeCP2/Rbfox/LASR protein super-large complex in mice with Rett syndrome

 Last Update: 2021-11-16
 Source: Internet
 Author: User

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Rett syndrome (Rett syndrome) is a neurodevelopmental disorder dominated by girls.

In order to understand the molecular functions of MeCP2, the researchers first used the optimized biochemical separation method of cell components and found that MeCP2 is a new component of the Rbfox/LASR (Large Assembly of Splicing Regulators) splicing complex through the IP/MS method

In summary, this work links the Rbfox/LASR splicing regulatory complex with Rett syndrome for the first time.

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After the mutation of MeCP2, the phase separation ability is weakened, and the MeCP2/Rbfox/LASR complex dissociates in mice with Rett syndrome

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