HUMAN BRAIN MAPPING: FC and structural connection measurement based on EEG and DTI help to study the posture control mechanism of traumatic brain injury

Traumatic brain injury (TBI) often leads to balance disorders, increases the risk of falls, and the chance of further injury
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However, the underlying neural mechanism of posture control after TBI is still unclear

Traumatic brain injury (TBI) often leads to balance disorders, increases the risk of falls, and the chance of further injury

Vikram Shenoy Handiru et al.

The purpose of this experiment is to study the graph theory properties of the FC diagram calculated from the source-constructed EEG in the balance disturbance task
.

This is the first report of changes in TBI's functional integration and separation in posture control tasks

The purpose of this experiment is to study the graph theory properties of the FC diagram calculated from the source-constructed EEG in the balance disturbance task

As a quantitative measure of brain network function integration and separation in posture tasks, the team calculated a global graph theory network measure of the brain function connections of source space EEG in different frequency bands
.

As a quantitative measure of brain network function integration and separation in posture tasks, the team calculated a global graph theory network measure of the brain function connections of source space EEG in different frequency bands
.

The picture on the left is a comparison of the displacement of the center of pressure (COP) (in centimeters)
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The picture on the right shows the comparison of BBS

The picture on the left is a comparison of the displacement of the center of pressure (COP) (in centimeters)

The TBI group showed lower balance performance in the displacement of the pressure center during the task and the Berg Balance Scale (BBS)

Spatial distribution of task-specific and significant voxels in the cerebral cortex within each group

Spatial distribution of task-specific and significant voxels in the cerebral cortex within each group

In addition, the reduction in alpha-band brain network separation from baseline to task is smaller in TBI than in HC
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The discovery of DTI showed extensive structural damage

In addition, the reduction in alpha-band brain network separation from baseline to task is smaller in TBI than in HC

In terms of neural correlation, it is observed that different frequency bands play different roles in the task: the modularity of theta band in the TBI group task is negatively correlated with BBS; the lower β-band network connectivity is related to the reduction of white matter structural integrity
.

In terms of neural correlation, it is observed that different frequency bands play different roles in the task: the modularity of theta band in the TBI group task is negatively correlated with BBS; the lower β-band network connectivity is related to the reduction of white matter structural integrity
.

This study used the global and topological metrics of FC and the structural integrity of WM to prove the neural relevance of balance defects and compared them with HC
.
This is the first time to study the separation and integration of brain networks in TBI population when performing posture control tasks on a computer stable measurement platform
.
Compared with HC, the EEG measurement results of TBI showed the changes in baseline and task modulation of NS, GE, and global graph theory measurement of the modularization of brain function networks
.
Interestingly, reduced network connection strength and integration, and greater network isolation are associated with worse balance performance (COP and BBS) and greater structural brain damage
.
The combined use of EEG-based FC measurement and DTI-based structural integrity measurement during the task helps to provide new insights into the underlying structure-function mechanism of posture control in TBI
.

This study used the global and topological metrics of FC and the structural integrity of WM to prove the neural relevance of balance defects and compared them with HC
.
This is the first time to study the separation and integration of brain networks in TBI population when performing posture control tasks on a computer stable measurement platform
.
Compared with HC, the EEG measurement results of TBI showed the changes in baseline and task modulation of NS, GE, and global graph theory measurement of the modularization of brain function networks
.
Interestingly, reduced network connection strength and integration, and greater network isolation are associated with worse balance performance (COP and BBS) and greater structural brain damage
.
The combined use of EEG-based FC measurement and DTI-based structural integrity measurement during the task helps to provide new insights into the underlying structure-function mechanism of posture control in TBI
.
The combined use of EEG-based FC measurement and DTI-based structural integrity measurement during the task helps to provide new insights into the underlying structure-function mechanism of posture control in TBI
.

These observations can pave the way for future studies to determine cortical biomarkers of TBI postural control defects, which may help clinicians and researchers better understand neuromuscular diseases
.

These observations can pave the way for future studies to determine cortical biomarkers of TBI postural control defects, which may help clinicians and researchers better understand neuromuscular diseases
.

Original source

Graph-theoretical analysis of EEG functional connectivity during balance perturbation in traumatic brain injury: A pilot study.
https://doi.
org/10.
1002/hbm.
25554

https://doi.
org/10.
1002/hbm.
25554 Leave a message here