Human caloric restriction reveals immune-metabolic regulators of health-span

Moderate reductions in food intake that do not cause malnutrition (caloric restriction) have beneficial effects on the healthspan and longevity of model organisms
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SpadaroWaitMeasures of immune function were studied in people who restricted caloric intake to around 14% over 2 years and in mice under 40% restriction (see Rhoads and Anderson)
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Cellular analysis and transcriptional investigations reveal improved thymic function under caloric restriction
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Expression of platelet-activating factor acetylhydrolase gene (PLA2G7) Human calories are decreasing
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Inactivation of this gene in mice reduced inflammation and improved markers of thymic function and certain metabolic functions in aging mice
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Therefore, expression decreasesPLA2G7Some of the beneficial effects of caloric restriction may be modulated -LBR Corporation

Summary

Caloric restriction (CR) of 40% in rodents results in increased lifespan, leading to trade-offs in growth, reproduction, and immune defense, which make it difficult to identify therapeutically relevant CR-mimicking targets
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We report that approximately 14% CR in healthy individuals for 2 years improves thymic function and is associated with the mobilization of ectopic lipids within the thymus
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Chromium-induced transcriptional reprogramming in adipose tissue is associated with mitochondrial bioenergetics, anti-inflammatory responses, and longevity
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gene expressionPla2g7Encoding platelet-activating factor acetylhydrolase (PLA2G7) is inhibited in humans receiving CR
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In mice, deletion of PLA2G7 showed reduced thymic lipoatrophy, protection from age-related inflammation, decreased NLRP3 inflammasome activation, and improved metabolic health