Human olfactory mucosal cell model

In collaboration with clinicians at Kuopio University Hospital, the researchers collected nasal biopsies from cognitively healthy individuals and patients diagnosed with Alzheimer's disease over several years

"This unique approach revealed damaged cells in the nasal cavity of Alzheimer's patients," said early researcher Riikka Lampinen.

The new cell model and findings were published today in the journal Cells

Alzheimer's is a devastating chronic disease for which there is currently no cure or effective treatment

The new findings from Associate Professor Katja Kanninen's research group may, in the future, provide important insights into why the majority of Alzheimer's patients experience disturbances in their sense of smell early in the pathogenesis of the disease

The olfactory mucosa is thought to be the entry point for air pollutants and viruses into the brain

Single-Cell RNA-Seq Analysis of Olfactory Mucosal Cells of Alzheimer's Disease Patients.