Hypertension promotes the development of cognitive impairment

A diagram of the occurrence of hypertension-promoting cognitive impairment
The clinical research team of Professor Tulip Tai of the Department of Neurology of Huashan Hospital affiliated with Fudan University, in cooperation with professor Tan Lan of Neurology of Qingdao Municipal Hospital, systematically evaluated, meta-analyzed and systematically studied 2214,814 subjects in relevant forward-looking observation studies that met the criteria. This study is of great significance for identifying individuals at higher risk of cognitive impairment and developing effective prevention strategies. The research results were published recently in Hypertension, which has attracted wide attention from the international medical community.
Tulip Tai, the team established a dose-response relationship between blood pressure levels and the risk of cognitive impairment, and determined the protective effects of anti-depressive drug use on cognitive function. The study showed that the effects of blood pressure on cognitive impairment are dependent on age and blood pressure type. In other words, high blood pressure in middle-life significantly increases the risk of cognitive impairment. Dose response analysis further found that the risk of cognitive impairment and dementia increased significantly when medium-term systolic blood pressure exceeded 130 mmHg levels. This is consistent with the latest american heart association's standard for the diagnosis of hypertension, 130/80 mmHg. However, there is no evidence of a significant link between high blood pressure and dementia in later life. However, high systolic pressure, low espressopressin, excessive blood pressure variability and low body temperature (abnormal blood pressure regulation, especially in older people) all increase the risk of cognitive impairment. Dose response analysis studies suggest that espressosis in later life is controlled at 90 to 100 mmHg levels, with the lowest risk of developing Alzheimer's disease (the most common type of dementia).
Tuliptai said that high blood pressure can lead to arteriosclerosis, chronic cerebral perfusion and microcirculation disorders, the brain hippocemia, temporal lobes, neurons of the cerebral cortivity are related to cognition, is very sensitive to istemia, it is easy because of high blood pressure atherosclerosis caused damage, so that the incidence of dementia increased. In addition, hypertension can also increase the accumulation of β-amyloid proteins( "old-age plaques") in the brain, neuron damage, and the formation of neurogenic fibers, leading to cognitive impairment, increasing the risk of dementia.
At the same time, the researchers further analyzed forward-looking studies on anti-hypernantigradation drugs and dementia risk, and found that the use of anti-hypernantigradation drugs, including diuretics, calcium channel blockers, and angiosin-converting enzyme inhibitors, may not only reduce the risk of dementia in cognitively normal people, but may also reduce the risk of progression to dementia in patients with mild cognitive impairment.
tulips stressed that in order to prevent cognitive impairment, we should establish a multi-dimensional, comprehensive and personalized blood pressure management strategy as soon as possible. (Source: Sun Guogen Huang Xin, China Science Journal)
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