"Hypertension" Which antihypertensive drug is safer?

Hypertension guidelines in the United States and Europe list 30 drugs in 5 different drug classes as possible options, but there are few face-to-face studies to help doctors determine which drug is better

People who are just starting to treat high blood pressure can also benefit from two different drugs-angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs)-according to a report published today in American Heart According to the analysis of real-world data in the Association’s Journal of Hypertension, ARBs have fewer drug side effects

Although antihypertensive drugs called angiotensin converting enzyme (ACE) inhibitors may be more common, angiotensin receptor blockers (ARBs) are equally effective and may have fewer side effects

This finding is based on an analysis of eight electronic health records and insurance claims databases in the United States, Germany, and South Korea, which included nearly 3 million patients who had taken hypertension medication for the first time and had no history of heart disease or stroke

Both of these drugs act on the renin-angiotensin-aldosterone system, which is a group of related hormones that work together to regulate blood pressure

"In professional guidelines, several types of drugs are also recommended as first-line treatment

The AHA/ACC 2017 "Guidelines for the Prevention, Detection, Evaluation and Management of Hypertension in Adults" stated that the main drugs for the treatment of hypertension are thiazide diuretics, ACE inhibitors, ARBs and calcium channel blockers because they have been proven Can reduce cardiovascular events

This study reviewed the health records of patients who used a single drug for antihypertensive therapy for the first time between 1996 and 2018

They found no significant differences in the incidence of heart attacks, strokes, heart failure hospitalizations, or any cardiac events

The risk of fluid accumulation and deep swelling of the skin and mucous membranes (angioedema) may be 3.

32% of people are more likely to cough (may be dry cough, persistent cough);

The possibility of sudden pancreatitis (pancreatitis) is 32% higher;

The possibility of gastrointestinal bleeding increased by 18%

Narrow selection

Data from electronic health records and insurance claims is challenging to use in research

Using this method, the researchers tracked four cardiovascular outcomes—heart attack, heart failure, stroke, and sudden cardiac death—and 51 adverse events after patients started antihypertensive therapy

Researchers found that the vast majority of patients (2.

Our research largely confirms that these two antihypertensive drugs have similar effects, although ARBs may be a little safer than ACE inhibitors

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