IDH wild-type diffuse glioma versus typical glioblastoma

Hayato Suzuki et al.

——Excerpt from the article chapter

【Ref: Suzuki H, et al.

Research background

Diffuse gliomas account for about 80% of primary malignant brain tumors in adults, classified as isocitrate dehydrogenase (IDH) wild type (IDHwt) or mutant type (IDHmut); The former is currently thought to be glioblastoma (GBM

There is currently no definite definition

The researchers extracted patient data from hospital databases, including age, sex, scope of resection, radiotherapy and chemotherapy regimens, and overall survival

Results of the study

The results of the NGS and MGMT promoter methylation assessment showed that the frequency of PI3K/MAPK pathway gene mutations was high (8 cases, 88.

The results of the survival analysis showed that the median follow-up period for this group of cases was 26.

The study investigated the clinical, histological and molecular features of IDHwt diffuse gliomas, and the results showed that IDHwt diffuse gliomas consisted mainly of low-grade gliomas, and that PI3K/MAPK pathway gene variants were found in most cases, but no other molecular features of GBM were found, which may not have progressed to GBM, which explains why the prognosis of this group of cases is better
than that of the reference sequence.