Illustrate what is dyskinesia caused by levodopa

 

Patients with Parkinson's disease may develop dyskinesia after taking levodopa for a long time
.

Dyskinesia is a dance-like, agitated or simply repetitive involuntary movement that mainly affects the trunk and limbs, and can also appear on the head and face

 

1.
Peak dosage form: It is caused by the increase of dopamine concentration in the nerve synaptic cleft and the excessive excitement of dopamine receptors after taking the medicine
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The movement of the limbs can start from the foot on the side with severe symptoms

1.

2.
Biphasic type: Appears at the beginning of the drug's onset and at the end of the dose.
It usually occurs in PD patients with a long course of disease, and often secondary to the peak-type dyskinesia
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It may be related to the instability of blood concentration caused by the decreased storage capacity of dopamine

2.
Biphasic type: Appears at the beginning of the drug's onset and at the end of the dose.
It usually occurs in PD patients with a long course of disease, and often secondary to the peak-type dyskinesia
.
It may be related to the instability of blood concentration caused by the decreased storage capacity of dopamine
.
It can increase the single dose and number of doses of levodopa preparations, and increase dopamine receptor agonists or catechol oxygen methyltransferase (COMT) inhibitors
.
3.
Off-phase dystonia: mostly occurs in the morning when the blood concentration of levodopa is low before taking the medicine
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Long-acting levodopa preparations or dopamine receptor agonists can be taken before going to bed
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