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Immune cells that clear Alzheimer's proteins are controlled by circadian rhythms

 Last Update: 2022-03-08
 Source: Internet
 Author: User

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Caption: Bright-field image of macrophages around the clock showing how circadian changes in cell-surface heparan sulfate proteoglycan (pink) impede the phagocytosis of the fluorescently tagged-amyloid (green)

Source: Gretchen Clark, CC-BY 4.

The immune cells responsible for clearing a key protein that builds up in the brains of Alzheimer's patients operate on a daily circadian rhythm, the researchers report

Alzheimer's disease is known to be associated with disturbances in the circadian rhythm, which controls many aspects of human behavior and physiology

In the new paper, the researchers investigated a molecular mechanism that may be involved in the link between Alzheimer's disease and circadian rhythms

New findings reveal a link between circadian rhythm disturbances and Alzheimer's disease

"Understanding how our circadian rhythms regulate heparin levels on the cell surface to control amyloid formation may lead to the development of chronotherapy to relieve symptoms of Alzheimer's disease and other inflammatory diseases," added Hurley

http://journals.

Citation:Clark GT, Yu Y, Urban CA, Fu G, Wang C, Zhang F, et al.

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