Immune memory lasts at least 8 months! New research has offered new hope for vaccine conservation and durability

A new study published in science journal Science Immunology shows that memory B cells for nucleocapsid proteins and nucleocapsid proteins (NCP) have increased rapidly in patients who have been infected with the new coronavirus for at least eight months.
results suggest that the new crown vaccine is likely to provide long-term protection for vaccinated people.
the study, a team of monash University academics from Australia conducted a long-term follow-up study of 25 COVID-19 patients, collecting a total of 36 blood samples from 4 to 242 days of symptoms.
11 of the patients were provided with two blood samples, one 21-106 days after the ont of symptoms and the other 116-242 days after the onsexuality, to compare the durability of immunity.
analysis of the meso-antibodies contained in these blood samples showed that the moderate antibody titration peaked about 20 days after coVID-19 symptoms, followed by a decrease.
of the 11 patients who took two repeated samples, the meso-antibody titration decreased in the second sample of all patients, with 7 patients with a moderate antibody titration below the positive standard.
study validates previous observations that levels of the new coronavirus's median antibodies will decline.
antibody titration changes over time (Photo: Reuters) and when researchers looked at memory B cells, they found a different picture.
B cells in all patients increased rapidly after coVID-19 symptoms appeared.
these memory B cells primarily express IgM antibodies, and over time, the proportion of memory B cells expressing IgG1 antibodies increased significantly.
this transformation reflects the normal process of B cell maturation.
IgM antibodies originally produced by B cells can also have a viral effect, but their melising effect is not necessarily the best.
B cells in the process of maturing through genetic mutations, adjust the affinity between antibodies and antigens, the generation of antigen affinity with higher, more resistant IgG antibodies.
Expression of the proportion of memory B cells produced by memory B cells against the new coronavirus prickly protein binding domain (RBD) antibody, dark gray for IgM antibodies, orange for IgG1 antibodies (Photo Source: Resources: Reference 3)) Analysis of long-term levels of memory B cells in patients showed that memory B cell levels remained stable in this study, especially in memory B cells that produced IgG, and that their proportion did not decrease in samples obtained more than 200 days after the on-on-the-oncrule of symptoms.
analysis of biomarkers of these cells also showed that they had the ability to respond quickly to a new coronavirus infection.
systemic immune memory can prevent severe COVID-19, making it possible for a new coronavirus infection to become only a mild or asymptomatic upper respiratory tract infection, the researchers said in a discussion of the paper.
The results are important because they clearly show that patients infected with the new coronavirus are able to maintain immunity to the virus and COVID-19, as the number of memory B cells (below) for the new coronavirus pyrethroid protein RBD and the number of memory B cells for the new coronavirus nucleoprotein (below) varies over time (blue data points represent 2 samples provided by a patient at different times, Picture Source: References. Dr Menno van Zelm, senior author of the
study and a professor in the Department of Immunology and Pathology at Monash University, said: "The persistence of the protection of the new crown vaccine has been clouded, and the results give hope that these vaccines will provide long-term protection.
: This article is intended to introduce medical and health research, not treatment options recommended.
if you need guidance on treatment options, visit a regular hospital.
resources: coVID immunity lasts up to 8 months, new data reveals. Retrieved December 28, 2020, from [2] Rodda et al., (2021). Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19. Cell, [3] Hartley et al. (2020). Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence. Science Immunology, 10.1126/sciimmunol.abf8891 [4] Memory B cells. Retrieved July 31, 2020, from。