Immunity: Antibacterial effects of a new subpopulation of intestinal epithelial cells, Tuft-2 cells and its mechanism

On March 22, 2022, Fan Zusen's group from the Institute of Biophysics, Chinese Academy of Sciences published an article titled "Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine" in the journal " Immunity ", which revealed that Tuft-2 cells, a new subset of intestinal epithelial cells, recognize the bacterial metabolite N-undecanoylglycine (N-C11-G, undecylglycine) through the vomeronasal receptor Vmn2r26, thereby participating in the clearance of intestinal anti-pathogenic bacteria and exerting a immune defense

The intestinal epithelium acts as the first barrier of the body's defense to separate the body from the external environment.

The function of Tuft cells has only attracted attention in recent years.

Fig.

Researcher Tian Yong and researcher Fan Zusen of the Institute of Biophysics, Chinese Academy of Sciences are the co-corresponding authors of this article, special assistant researcher Xiong Zhen, senior engineer Zhu Xiaoxiao, doctoral students Geng Jingjing and Xu Yuwei are the co-first authors

Article link: https://

(Contributed by: Fan Zusen Research Group)