Immunity: Wuhan University reveals the pathogenesis of cancer cachexia: gut-kidney immune axis and uric acid metabolism

On August 26, 2022, the international academic journal Immunity ("Immunity") published online the research group of Wuhan University Medical Research Institute, Frontier Science Center of Immunity and Metabolism, Zhongnan Hospital and Taikang Life Medical Center on the pathogenesis of cancer cachexia.

Paper titled "Renal NF-κB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of organ wasting"

Cancer cachexia, or tumor-induced host wasting, is a systemic metabolic syndrome with weight loss (including fat and muscle loss), hyperglycemia, and high mortality, leading directly to At least 20% of cancer patients die

As an evolutionarily conserved model organism, Drosophila has become an ideal model to study tumor-induced host depletion in recent years

Figure 1.

In this study, the researchers induced intestinal stem cells to over-proliferate to form intestinal malignancies by overexpressing the activated transcription factor yki3SA (homolog of human YAP1) in the Drosophila gut, resulting in body consumption and shortened lifespan

Therefore, this study found that environmental microbes, gut bacteria, renal IMD-NF-κB immune response and uric acid metabolism are important factors in the death of malignant tumors, independent of the currently known tumor-related body consumption.

Song Wei's research group has been engaged in the research of organ communication and immune metabolism regulation for a long time, mainly focusing on secreted proteins mediating intestinal/intestinal tumors to remotely regulate the immune and metabolic balance of important organs in the body.

Figure 2.

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