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Science and Technology Daily (Reporter Wu Chunxin, Correspondent Du Weiwei and Yang Cen) On October 25, the reporter learned from the People’s Hospital of Wuhan University that the latest issue of the top international cardiovascular journal "Journal of the American College of Cardiology" published the Department of Cardiology Hu The latest research progress of arrhythmia in Professor Dan's research group: SCN5A, which encodes cardiac sodium channels, is the main pathogenic gene of early repolarization syndrome that can lead to sudden cardiac death
.
This research has great clinical significance for the early detection and prevention of sudden cardiac death caused by early repolarization syndrome
.
It is estimated that the number of sudden cardiac deaths accounts for more than 80% of the total number of sudden deaths
.
Hu Dan introduced that J wave syndrome is a clinical syndrome with fatal arrhythmia characterized by electrocardiogram J wave
Hu Dan said that J wave syndrome mainly includes Brugada syndrome and early repolarization syndrome
.
Both of the first clinical manifestations can be manifested as sudden death, which seriously threatens the life safety of patients
Professor Hu Dan’s research team found that SCN5A, which encodes cardiac sodium channels, is the main pathogenic gene of early repolarization syndrome; patients with J wave syndrome who carry multiple SCN5A pathogenic mutations have a significantly higher risk of malignant events Patients with a single SCN5A mutation
.
The research team also found the first patient with early repolarization syndrome induced by fever and identified the pathogenic mutation in this patient
.
This mutation leads to the complete loss of sodium ion channel function, makes the structure of sodium ion channel protein unstable, and shows a negative dominant effect, which is aggravated in a fever state
The above-mentioned research results provide a new method for the accurate identification of sudden cardiac death in the early clinical stage, and may change the relevant clinical guidelines and diagnosis and treatment decisions
.
Hu Dan said that by screening patients for the presence of the SCN5A gene, cardiovascular physicians can actively and effectively screen high-risk groups of early repolarization syndrome from the population, thereby effectively preventing sudden cardiac death caused by early repolarization syndrome.
