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Improved microbial therapy obtains clinical proof-of-concept for the treatment of genetic and metabolic diseases

 Last Update: 2021-09-28
 Source: Internet
 Author: User

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Recently, Synlogic announced that its microbial therapies SYNB1618 and SYNB1934 modified by synthetic biology have achieved positive results in a phase 2 clinical trial for the treatment of patients with phenylketonuria (PKU).

Phenylketonuria is an inherited metabolic disease.

Synlogic was co-founded by Dr.

The results of the phase 2 clinical trial showed that the fasting plasma phenylalanine level of patients receiving SYNB1618 treatment (dose of 1e12 live bacteria) decreased by 20% at 14 days.

▲The effect of SYNB1618 in reducing the level of phenylalanine (picture source: Synlogic official website)

SYNB1934 is an improved strain evolved from SYNB1618, which has a stronger ability to degrade phenylalanine

Image source: Synlogic's official website

Reference materials:

[1] Synlogic Announces Positive Phase 2 Data Demonstrating Reduction in Plasma Phenylalanine Levels in Patients with Phenylketonuria.

[2] Phenylketonuria Clinical Program Update 20 September 2021.

(The original text has been deleted)

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