In 10 years' time, it is expected to reverse the body's aging through cell reprogramming.

Two white, eye angle fishtail pattern, the more dim eyes, it will take longer to recover from injury ... In the face of obvious signs of aging, most people fantasize about returning to old age.
a 2011 study, scientists reprogrammed cells from 101-year-old humans in-body to remove the aging-related metagenetic modifications of those cells, and the metabolic patterns of those cells became consistent with those of young people.
but whether this kind of time backflow, the way to restore youth can also be achieved in life, the past has not been determined.
, scientists at the Salk Institute have found that gene expression, often associated with embryonic state, can reverse signs of aging.
This method not only re-youngers cultured human skin cells, but also "returns to old age" in mice with premature aging, reversing some signs of aging and extending the lifespan of mice by 30 percent.
early research provides insights into cell-driven and possible treatments for improving human health and longevity in the aging process. Professor Carlos Izpisua Belmonte, of the Salk Institute's Gene Expression Laboratory, said:
Our study shows that aging is not one-way, but malleable, and that by regulating it, it can even be reversed.
with the increase in modern life expectancy, the risk of geriatric disease is also increasing.
, the data show that age is the biggest risk factor for heart disease, cancer and neurodegenerable diseases.
to reverse aging is the study of cell reprogramming.
reprogramming was invented in 2006 by Japanese scholar Yamano Yamano, to convert adult cells into induced erythmic stem cells by introducing four transcription factors.
induced erythnic stem cells have the same ability to differentiate into cells as embryonic stem cells.
are widely used to reprogram cells, one of which is used to reverse aging, but the experimental mice in previous studies either died early or developed cancer.
and other stem cell labs have observed that when you induce cell reprogramming, cells look younger," said Alejandro Ocampo, lead author of the paper.
next question is whether we can re-exist the process in living animals.
" While cell reversal aging sounds good, the process that is often suitable for laboratory culture of cells is not necessarily suitable for complete organisms.
, although rapid cell division is important for growing embryos, it is also one of the main signs of cancer in adults.
, for example, returning large numbers of adult cells to the embryonic state can lead to organ failure and even death.
for these reasons, the team was considering whether cancer could be avoided, and the researchers used some reprogramming techniques this time.
to find out, they turned their attention to early aging in children with rare diseases.
they developed a genetic defect in the expression of premature aging (HGPS), which showed many signs of aging, such as DNA damage, reduced organ function, and shorter life expectancy.
addition, the appearance of genetic markers on DNA responsible for gene regulation and genomic protection can be prematurely abnormally expressed.
important, the overt genetic markers are modified during cell reprogramming.
The Sapk Institute has found that some cell reprogramming can reverse signs of cell aging, such as the accumulation of DNA damage.
left is fibroblasts in mice with premature aging, and on the right is fibroblasts in mice with premature aging that are reprogrammed.
cell reprogramming usually takes 2 to 3 weeks to convert adult cells into induced erythmatic stem cells, but they only use the above transcription factor reprogramming for 2 to 4 days, so what is obtained is not induced erythmatic stem cells.
that after this treatment, the formed skin cells were still skin cells, but the signs of aging in the cells were reduced.
the results of this phase, the team used the same short-term reprogramming method for live mice with early aging.
results were alarming: mice that received cell reprogramming looked younger and had improved cardiovascular and other organ function compared to mice that had not received treatment.
most surprising thing is that they live 30 per cent longer and don't get cancer.
at the cellular level, not only were signs of molecular aging reversed in mice with premature aging, but the same effect was seen in normal aging mice.
the introduction of cell reprogramming improved muscle regeneration in older mice.
left is a muscle repair in normal aging mice.
picture on the right is muscle repair in mice that have undergone cell reprogramming.
, one of the study's most important researchers, said: "This study shows that presuppaled genetic changes drive aging in at least part.
it gives us an understanding of which path paths can be used to slow cell aging.
, Salk's scientists shifted their focus to ordinary aging mice.
for these mice, some reprogramming techniques improve the regeneration of the pancreas and muscles.
, the injured pancreas and muscles recover more quickly, suggesting that cell reprogramming can significantly improve quality of life.
, a professor at Izpisua Belmonte, said: "Obviously, mice are not human, and we know that it can be more complicated if people go back to old age.
but this study shows that aging is a dynamic and elastic process that can be interfered with through treatment.
" Salk researchers believe that inducing supergenetic changes through chemicals or small molecules may be the most promising way to get humans back to old age.
, however, warn that the treatment could take more than a decade to enter clinical trials because of the complexity of aging.
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