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▎WuXi AppTec Content Team Editor Recently, the American Cancer Society (ACS) released the 2022 U.
S.
Cancer Statistics in CA: A Cancer Journal for Clinicians, known as the "magical journal".
report
.
The report shows that since 1991, the cancer death rate in the United States has continued to decline
.
As of 2019 (with a 2-4 year delay in the statistics of cancer data), the cancer mortality rate has dropped by 32%, and about 3.
5 million cancer deaths have been avoided
.
What factors have contributed to the continued decline in cancer mortality? What are the trends in incidence and mortality of different types of cancer? What are the trends in cancer incidence and death in the United States in 2022? Let's take a look at how the report is presented
.
Screenshot source: CA: A Cancer Journal for Clinicians Cancer Death Rates Continue to Decline The report states that between 1991-2019, cancer deaths in the United States fell by 32%
.
The rate of decline accelerated slowly from about 1% per year in the late 1990s to 1.
5% per year in the early 2000s and 2% per year between 2015-2019
.
The decline in cancer mortality is largely driven by a decline in lung cancer mortality
.
At the same time, advances in treatment options and early detection of other types of cancer also play an important role
.
Due to the development of targeted therapy, the survival of patients with hematological and lymphoid malignancies has been extended particularly rapidly
.
For example, the 5-year relative survival rate for chronic myeloid leukemia increased from 22% in the mid-1970s to 71% between 2011-2017
.
Immunotherapy, most notably in combination with anti-CTLA4 and anti-PD-1 checkpoint inhibitors, in the treatment of metastatic melanoma, improved 5-year relative survival in patients, from 15% in 2004 to 2011-2017 30% of the year
.
From the mid-1970s to 2011-2017, the 5-year relative survival rate for all cancers increased from 49% overall to 68%
.
Prostate cancer (98%), melanoma (93%) and female breast cancer (90%) had the highest 5-year relative survival rates, pancreatic cancer (11%), liver and esophageal cancer (20%) and lung cancer (22%) The 5-year relative survival rate is the lowest
.
Image Credit: 123RF Lung Cancer Death Rate Drops Dramatically Lung cancer is the leading cause of cancer death in the United States, with more than 350 people dying every day from lung cancer
.
About 81 percent of deaths from lung cancer are directly caused by smoking, and smokers have about 25 times the risk of developing lung cancer than those who never smoke
.
In addition, 3% of lung cancer deaths are caused by secondhand smoke
.
Lung cancer mortality rates have declined dramatically in recent years due to declining smoking numbers, early detection, and advances in treatment
.
Overall: Lung cancer death rates fell by 56% in men from 1990-2019 and by 32% in women from 2002-2019
.
Lung cancer mortality in men accelerated from a 3.
1% annual decline in 2010-2014 to 5.
4% in 2015-2019; in women, it accelerated from a 1.
8% decline to 4.
3% per year
.
Advances in early detection of lung cancer have greatly increased the rate of early detection of lung cancer
.
From 2014 to 2018, the rate of early-stage lung cancer increased by 4.
5% per year, while the rate of advanced-stage lung cancer decreased sharply
.
In 2018, 28% of lung cancers were detected at an early stage, compared to just 17% in 2004
.
The rapid development of innovative treatments has also contributed to the decline in lung cancer mortality
.
In particular, advances in the treatment of non-small cell lung cancer (NSCLC), the most common subtype of lung cancer, such as video-assisted thoracoscopic surgery (VATS), targeting the most common driver mutations in epidermal growth factor receptor (EGFR) and anaplastic lymph nodes Oncokinase (ALK) tyrosine kinase inhibitors, as well as immunotherapy, have significantly improved the survival of patients with non-small cell lung cancer
.
Nearly one-third (31%) of lung cancer patients survived 3 years after diagnosis, compared with 21% 10 years ago
.
Image credit: 123RF Breast cancer mortality decline slowed Between 2014-2018, the incidence of breast cancer in women continued to increase slowly (0.
5% per year), which was significantly associated with decreased fertility, the onset of childbearing after age 30, and weight gain association
.
Breast cancer mortality in women peaked in 1989
.
Since then, with improvements in early diagnosis, mammography, and treatment, the death rate from breast cancer in women dropped by 42% between 1989 and 2019
.
However, the rate of decline in female breast cancer mortality has slowed in recent years
.
A decline of 2%-3% per year from the 1990s to the early 2000s slowed to a decline of 1% per year from 2013-2019
.
The rate of decline in prostate cancer mortality stabilized in the 1990s and early 2000s, with the widespread adoption of prostate-specific antigen (PSA) testing and advances in treatment, prostate cancer mortality declined by 53% between 1993-2018
.
But in recent years, prostate cancer mortality rates have fallen by only 0.
6% per year
.
This is related to changes in prostate cancer screening guidelines by the US Preventive Services Task Force (USPSTF)
.
In 2008, the USPSTF recommended against routine screening with PSA testing for men 75 years of age and older; in 2012, it recommended against PSA testing for all men
.
The USPSTF pointed out that although PSA testing can help detect prostate cancer early and reduce mortality, there is growing evidence that PSA testing may lead to overdiagnosis and overtreatment of prostate cancer
.
From 2014 to 2018, the incidence of early-stage prostate cancer remained stable, while the incidence of advanced-stage prostate cancer increased by 4%-6% per year
.
Over the past 10 years, the rate of diagnosed advanced prostate cancer increased from 3.
9% in 2007 to 8.
2% in 2018
.
Image credit: 123RF Rising colorectal cancer mortality in young adults Overall, colorectal cancer incidence and mortality decreased, but young adults (under 50 years old) increased incidence and mortality
.
Since 1978, colorectal cancer mortality in men has fallen by 55%; since 1969, colorectal cancer mortality in women has decreased by 60%
.
Between 2014 and 2018, the incidence of colorectal cancer in people aged 50 years and older decreased by about 2% per year, but the incidence in young adults increased by 1.
5% per year
.
Colorectal cancer mortality declined by about 2% per year between 2010 and 2019, but colorectal cancer mortality in young adults increased by 1.
2% per year between 2005 and 2019
.
The reasons for the rise in colorectal cancer incidence and mortality in young adults, although unclear, may be related to changes in the life>
.
Cervical cancer prevention needs to be strengthened Although cervical cancer is one of the most preventable cancers, it is still the second leading cause of cancer death in women aged 20-39
.
In 2019, a total of 4,152 women died from cervical cancer, which equates to at least 10 deaths a day from this cancer, half of which occurred in women aged 50 or younger
.
The report highlights the need for increased cervical cancer screening and human papillomavirus (HPV) vaccination among women to reduce the risk of cervical cancer incidence and mortality
.
Image source: 123RF Other types of cancer incidence and mortality changes After decades of growth, the incidence of thyroid cancer is declining at an annual rate of 2.
5% between 2014 and 2018
.
Pancreatic cancer is the third leading cause of cancer death for both men and women in the United States, between 2000 and 2019: The mortality rate for men increased slowly, from 12.
1 to 12.
7 per 100,000 people; the mortality rate for women remained relatively stable, at 9.
3/100,000 to 9.
6/100,000
.
Mortality rates from liver cancer have increased rapidly for decades, but have remained stable for both men and women over the last 5 years
.
From 2010 to 2019, the mortality rate of oropharyngeal cancer increased by 0.
4% per year; tongue, tonsil, and oropharyngeal cancers caused by human papillomavirus increased by about 2% per year in men and 1% per year in women
.
Beginning in the mid-1970s, the incidence of non-Hodgkin lymphoma finally began to decline after increasing
.
Image credit: 123RF Child and Adolescent Cancer Mortality Declines Significantly Cancer is the second most common cause of death among U.
S.
children (ages 1-14), after accidents; and the fourth-most common cause of death among adolescents (ages 15-19) reason
.
In 2022, 10,470 children and 5,480 adolescents are expected to develop cancer, with 1,050 and 550 deaths due to cancer, respectively
.
Leukemia is the most common childhood cancer, accounting for 28% of childhood cancers, followed by brain and other central nervous system tumors (26%)
.
Among adolescents, the most common type of cancer was tumors of the brain and other central nervous system (21%), followed by lymphoma (19%)
.
Overall cancer rates in children and adolescents have increased slightly at a rate of 0.
8% per year since 1975
.
In contrast, between 1970 and 2019, cancer deaths in children and adolescents fell by 71% and 61%, respectively, due to factors such as improved treatment and more people participating in clinical trials
.
The dramatic decline in childhood and adolescent cancer mortality was also associated with a sharp decline in leukemia mortality
.
Between 1970-2019: Leukemia death rates fell by 84% in children and 75% in adolescents
.
Mortality rates from non-Hodgkin lymphoma decreased by 91% and 67% among children and adolescents, respectively; mortality from brain and other central nervous system tumors decreased by 41% and 23%, respectively
.
The 5-year relative survival rate for childhood cancer increased from 58% in the mid-1970s to 85% in 2011-2017; it increased from 68% to 86% in adolescents
.
Image credit: 123RF Achievements but still needs to be done The report states that despite a combined 32% reduction in cancer death rates since 1991, cancer is projected to remain the leading cause of death in the U.
S.
with more than 1.
9 million deaths in 2022 cases of new cancers and 610,000 cancer deaths
.
Cancer will account for 21% of deaths in both men and women, the second leading cause of death after heart disease
.
The lifetime risk of cancer was 40.
2% for men and 38.
5% for women
.
The reasons for the higher cancer risk in men, although not fully understood, are likely to be largely related to greater exposure to carcinogenic environmental and biological factors, such as smoking and height
.
In addition, sex differences in endogenous hormones, immune function, and responses may also play a role
.
The most common causes of cancer deaths in men are lung, prostate and colorectal cancers; in women, lung, breast and colorectal cancers
.
▲The type, number and proportion of common new cancers estimated by the American Cancer Society in 2022 for different genders (Data source: Reference [1]; Drawing: WuXi AppTec Content Team) ▲The American Cancer Society Estimated by 2022 Common cancer deaths, numbers and proportions in different gender populations (Data source: Reference [1]; Drawing: WuXi AppTec Content Team) The summary report concluded that at least 42% of new cancers are preventable, including 19% of new cancers are caused by smoking, and at least 18% are caused by a combination of being overweight or obese, drinking alcohol, eating an unhealthy diet and being physically inactive
.
At the same time, screening can also detect early detection of cancers, such as breast, prostate and colorectal cancer; there are also some cancers that are highly preventable, such as cervical cancer
.
These preventable factors should be targeted to reduce the risk of cancer incidence and death, which will undoubtedly accelerate our progress in the fight against cancer
.
Recommended reading Stick to these 5 good habits, let serious illness go around you! It's a pity that not many people do it all.
The man fell into a coma and was admitted to the hospital after taking a bath.
It has nothing to do with gas poisoning! Reminder: In winter, these people should keep in mind "3 no-washing" to promote brain health, and the risk of dementia is expected to be reduced by 28%! This little thing is too important to "feel like living in hell every day": 1 in 5 mothers suffers from postpartum depression! The 6 benefits of singing are closely related to longevity? Long experience! References [1] Rebecca L.
Siegel, et al.
, ( 2022).
Cancer Statistics, 2022.
CA: A Cancer Journal for Clinicians, DOI: https://doi.
org/10.
3322/caac.
21708.
[2] Risk of Dying from Cancer Continues to Drop at an Accelerated Pace.
Retrieved Jan 13 ,2022, from https:// Cancer Facts & Figures 2022.
Retrieved Jan 13, 2022, from https:// US Cancer Deaths Continue to Fall, Especially Lung Cancer.
Retrieved Jan 13 ,2022,from https://#[5] Progress on lung cancer drives overall decline in US cancer deaths.
Retrieved Jan 13 ,2022,
.
This article is for information exchange purposes only, and the views expressed in this article do not represent WuXi AppTec's position, nor do they represent WuXi AppTec's support or opposition to the views expressed in this article
.
This article is also not a treatment plan recommendation
.
For guidance on treatment options, please visit a regular hospital
.
S.
Cancer Statistics in CA: A Cancer Journal for Clinicians, known as the "magical journal".
report
.
The report shows that since 1991, the cancer death rate in the United States has continued to decline
.
As of 2019 (with a 2-4 year delay in the statistics of cancer data), the cancer mortality rate has dropped by 32%, and about 3.
5 million cancer deaths have been avoided
.
What factors have contributed to the continued decline in cancer mortality? What are the trends in incidence and mortality of different types of cancer? What are the trends in cancer incidence and death in the United States in 2022? Let's take a look at how the report is presented
.
Screenshot source: CA: A Cancer Journal for Clinicians Cancer Death Rates Continue to Decline The report states that between 1991-2019, cancer deaths in the United States fell by 32%
.
The rate of decline accelerated slowly from about 1% per year in the late 1990s to 1.
5% per year in the early 2000s and 2% per year between 2015-2019
.
The decline in cancer mortality is largely driven by a decline in lung cancer mortality
.
At the same time, advances in treatment options and early detection of other types of cancer also play an important role
.
Due to the development of targeted therapy, the survival of patients with hematological and lymphoid malignancies has been extended particularly rapidly
.
For example, the 5-year relative survival rate for chronic myeloid leukemia increased from 22% in the mid-1970s to 71% between 2011-2017
.
Immunotherapy, most notably in combination with anti-CTLA4 and anti-PD-1 checkpoint inhibitors, in the treatment of metastatic melanoma, improved 5-year relative survival in patients, from 15% in 2004 to 2011-2017 30% of the year
.
From the mid-1970s to 2011-2017, the 5-year relative survival rate for all cancers increased from 49% overall to 68%
.
Prostate cancer (98%), melanoma (93%) and female breast cancer (90%) had the highest 5-year relative survival rates, pancreatic cancer (11%), liver and esophageal cancer (20%) and lung cancer (22%) The 5-year relative survival rate is the lowest
.
Image Credit: 123RF Lung Cancer Death Rate Drops Dramatically Lung cancer is the leading cause of cancer death in the United States, with more than 350 people dying every day from lung cancer
.
About 81 percent of deaths from lung cancer are directly caused by smoking, and smokers have about 25 times the risk of developing lung cancer than those who never smoke
.
In addition, 3% of lung cancer deaths are caused by secondhand smoke
.
Lung cancer mortality rates have declined dramatically in recent years due to declining smoking numbers, early detection, and advances in treatment
.
Overall: Lung cancer death rates fell by 56% in men from 1990-2019 and by 32% in women from 2002-2019
.
Lung cancer mortality in men accelerated from a 3.
1% annual decline in 2010-2014 to 5.
4% in 2015-2019; in women, it accelerated from a 1.
8% decline to 4.
3% per year
.
Advances in early detection of lung cancer have greatly increased the rate of early detection of lung cancer
.
From 2014 to 2018, the rate of early-stage lung cancer increased by 4.
5% per year, while the rate of advanced-stage lung cancer decreased sharply
.
In 2018, 28% of lung cancers were detected at an early stage, compared to just 17% in 2004
.
The rapid development of innovative treatments has also contributed to the decline in lung cancer mortality
.
In particular, advances in the treatment of non-small cell lung cancer (NSCLC), the most common subtype of lung cancer, such as video-assisted thoracoscopic surgery (VATS), targeting the most common driver mutations in epidermal growth factor receptor (EGFR) and anaplastic lymph nodes Oncokinase (ALK) tyrosine kinase inhibitors, as well as immunotherapy, have significantly improved the survival of patients with non-small cell lung cancer
.
Nearly one-third (31%) of lung cancer patients survived 3 years after diagnosis, compared with 21% 10 years ago
.
Image credit: 123RF Breast cancer mortality decline slowed Between 2014-2018, the incidence of breast cancer in women continued to increase slowly (0.
5% per year), which was significantly associated with decreased fertility, the onset of childbearing after age 30, and weight gain association
.
Breast cancer mortality in women peaked in 1989
.
Since then, with improvements in early diagnosis, mammography, and treatment, the death rate from breast cancer in women dropped by 42% between 1989 and 2019
.
However, the rate of decline in female breast cancer mortality has slowed in recent years
.
A decline of 2%-3% per year from the 1990s to the early 2000s slowed to a decline of 1% per year from 2013-2019
.
The rate of decline in prostate cancer mortality stabilized in the 1990s and early 2000s, with the widespread adoption of prostate-specific antigen (PSA) testing and advances in treatment, prostate cancer mortality declined by 53% between 1993-2018
.
But in recent years, prostate cancer mortality rates have fallen by only 0.
6% per year
.
This is related to changes in prostate cancer screening guidelines by the US Preventive Services Task Force (USPSTF)
.
In 2008, the USPSTF recommended against routine screening with PSA testing for men 75 years of age and older; in 2012, it recommended against PSA testing for all men
.
The USPSTF pointed out that although PSA testing can help detect prostate cancer early and reduce mortality, there is growing evidence that PSA testing may lead to overdiagnosis and overtreatment of prostate cancer
.
From 2014 to 2018, the incidence of early-stage prostate cancer remained stable, while the incidence of advanced-stage prostate cancer increased by 4%-6% per year
.
Over the past 10 years, the rate of diagnosed advanced prostate cancer increased from 3.
9% in 2007 to 8.
2% in 2018
.
Image credit: 123RF Rising colorectal cancer mortality in young adults Overall, colorectal cancer incidence and mortality decreased, but young adults (under 50 years old) increased incidence and mortality
.
Since 1978, colorectal cancer mortality in men has fallen by 55%; since 1969, colorectal cancer mortality in women has decreased by 60%
.
Between 2014 and 2018, the incidence of colorectal cancer in people aged 50 years and older decreased by about 2% per year, but the incidence in young adults increased by 1.
5% per year
.
Colorectal cancer mortality declined by about 2% per year between 2010 and 2019, but colorectal cancer mortality in young adults increased by 1.
2% per year between 2005 and 2019
.
The reasons for the rise in colorectal cancer incidence and mortality in young adults, although unclear, may be related to changes in the life>
.
Cervical cancer prevention needs to be strengthened Although cervical cancer is one of the most preventable cancers, it is still the second leading cause of cancer death in women aged 20-39
.
In 2019, a total of 4,152 women died from cervical cancer, which equates to at least 10 deaths a day from this cancer, half of which occurred in women aged 50 or younger
.
The report highlights the need for increased cervical cancer screening and human papillomavirus (HPV) vaccination among women to reduce the risk of cervical cancer incidence and mortality
.
Image source: 123RF Other types of cancer incidence and mortality changes After decades of growth, the incidence of thyroid cancer is declining at an annual rate of 2.
5% between 2014 and 2018
.
Pancreatic cancer is the third leading cause of cancer death for both men and women in the United States, between 2000 and 2019: The mortality rate for men increased slowly, from 12.
1 to 12.
7 per 100,000 people; the mortality rate for women remained relatively stable, at 9.
3/100,000 to 9.
6/100,000
.
Mortality rates from liver cancer have increased rapidly for decades, but have remained stable for both men and women over the last 5 years
.
From 2010 to 2019, the mortality rate of oropharyngeal cancer increased by 0.
4% per year; tongue, tonsil, and oropharyngeal cancers caused by human papillomavirus increased by about 2% per year in men and 1% per year in women
.
Beginning in the mid-1970s, the incidence of non-Hodgkin lymphoma finally began to decline after increasing
.
Image credit: 123RF Child and Adolescent Cancer Mortality Declines Significantly Cancer is the second most common cause of death among U.
S.
children (ages 1-14), after accidents; and the fourth-most common cause of death among adolescents (ages 15-19) reason
.
In 2022, 10,470 children and 5,480 adolescents are expected to develop cancer, with 1,050 and 550 deaths due to cancer, respectively
.
Leukemia is the most common childhood cancer, accounting for 28% of childhood cancers, followed by brain and other central nervous system tumors (26%)
.
Among adolescents, the most common type of cancer was tumors of the brain and other central nervous system (21%), followed by lymphoma (19%)
.
Overall cancer rates in children and adolescents have increased slightly at a rate of 0.
8% per year since 1975
.
In contrast, between 1970 and 2019, cancer deaths in children and adolescents fell by 71% and 61%, respectively, due to factors such as improved treatment and more people participating in clinical trials
.
The dramatic decline in childhood and adolescent cancer mortality was also associated with a sharp decline in leukemia mortality
.
Between 1970-2019: Leukemia death rates fell by 84% in children and 75% in adolescents
.
Mortality rates from non-Hodgkin lymphoma decreased by 91% and 67% among children and adolescents, respectively; mortality from brain and other central nervous system tumors decreased by 41% and 23%, respectively
.
The 5-year relative survival rate for childhood cancer increased from 58% in the mid-1970s to 85% in 2011-2017; it increased from 68% to 86% in adolescents
.
Image credit: 123RF Achievements but still needs to be done The report states that despite a combined 32% reduction in cancer death rates since 1991, cancer is projected to remain the leading cause of death in the U.
S.
with more than 1.
9 million deaths in 2022 cases of new cancers and 610,000 cancer deaths
.
Cancer will account for 21% of deaths in both men and women, the second leading cause of death after heart disease
.
The lifetime risk of cancer was 40.
2% for men and 38.
5% for women
.
The reasons for the higher cancer risk in men, although not fully understood, are likely to be largely related to greater exposure to carcinogenic environmental and biological factors, such as smoking and height
.
In addition, sex differences in endogenous hormones, immune function, and responses may also play a role
.
The most common causes of cancer deaths in men are lung, prostate and colorectal cancers; in women, lung, breast and colorectal cancers
.
▲The type, number and proportion of common new cancers estimated by the American Cancer Society in 2022 for different genders (Data source: Reference [1]; Drawing: WuXi AppTec Content Team) ▲The American Cancer Society Estimated by 2022 Common cancer deaths, numbers and proportions in different gender populations (Data source: Reference [1]; Drawing: WuXi AppTec Content Team) The summary report concluded that at least 42% of new cancers are preventable, including 19% of new cancers are caused by smoking, and at least 18% are caused by a combination of being overweight or obese, drinking alcohol, eating an unhealthy diet and being physically inactive
.
At the same time, screening can also detect early detection of cancers, such as breast, prostate and colorectal cancer; there are also some cancers that are highly preventable, such as cervical cancer
.
These preventable factors should be targeted to reduce the risk of cancer incidence and death, which will undoubtedly accelerate our progress in the fight against cancer
.
Recommended reading Stick to these 5 good habits, let serious illness go around you! It's a pity that not many people do it all.
The man fell into a coma and was admitted to the hospital after taking a bath.
It has nothing to do with gas poisoning! Reminder: In winter, these people should keep in mind "3 no-washing" to promote brain health, and the risk of dementia is expected to be reduced by 28%! This little thing is too important to "feel like living in hell every day": 1 in 5 mothers suffers from postpartum depression! The 6 benefits of singing are closely related to longevity? Long experience! References [1] Rebecca L.
Siegel, et al.
, ( 2022).
Cancer Statistics, 2022.
CA: A Cancer Journal for Clinicians, DOI: https://doi.
org/10.
3322/caac.
21708.
[2] Risk of Dying from Cancer Continues to Drop at an Accelerated Pace.
Retrieved Jan 13 ,2022, from https:// Cancer Facts & Figures 2022.
Retrieved Jan 13, 2022, from https:// US Cancer Deaths Continue to Fall, Especially Lung Cancer.
Retrieved Jan 13 ,2022,from https://#[5] Progress on lung cancer drives overall decline in US cancer deaths.
Retrieved Jan 13 ,2022,
.
This article is for information exchange purposes only, and the views expressed in this article do not represent WuXi AppTec's position, nor do they represent WuXi AppTec's support or opposition to the views expressed in this article
.
This article is also not a treatment plan recommendation
.
For guidance on treatment options, please visit a regular hospital
.
