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    Home > Biochemistry News > Microbiology News > In vitro test: mutant new coronavirus discovered in South Africa may reduce the effect of Pfizer vaccine

    In vitro test: mutant new coronavirus discovered in South Africa may reduce the effect of Pfizer vaccine

    • Last Update: 2021-03-25
    • Source: Internet
    • Author: User
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    A recent study shows that the B.
    1.
    351 new crown variant strain first discovered in South Africa may reduce the antibody protection of the new crown vaccine jointly developed by Pfizer and BioNTech in Germany by two-thirds.

    According to a CNN report on the 17th, researchers from Pfizer and the University of Texas Medical Department (UTMB) have genetically engineered the new coronavirus to carry some of the mutations found in the mutant strain B.
    1.
    351.

    The researchers collected serum samples from 15 vaccinators who had received two doses of Pfizer-BioNTech vaccine for in vitro tests.

    The study showed that compared with the original new coronavirus strain, the Pfizer-BioNTech vaccine's antibody protection against artificially modified strains was reduced by two-thirds.

    The preliminary results of the study were published in the medical journal "New England Journal of Medicine" on February 17.

    In response to the results of the study, a researcher from the University of Texas Medical Department said in an interview that although the mutant virus may reduce the effectiveness of the Pfizer-BioNTech vaccine, the vaccine still has a protective effect against the new coronavirus.

    Pfizer and BioNTech also stated that the vaccine still has a neutralizing effect on the new coronavirus, and there are no human experiments showing that this mutant virus will reduce the vaccine effect.

    After the mutated virus was discovered in the United Kingdom, South Africa and other countries, many countries have reported cases of mutated virus infection in the country.
    How to deal with the possible crisis caused by the mutated virus has become one of the focuses of the governments and vaccine researchers of various countries.
    Many vaccines are developed.
    The company has conducted research on the threat of new crown mutations to vaccine protection.The results of two studies published by the University of Oxford and AstraZeneca at the beginning of this month stated that their joint-developed new crown vaccine has an effective rate of 75% against the mutant virus found in the UK, but it is effective against the mutant virus found in South Africa.
    The efficacy of mild disease is limited.

    At present, the South African government has suspended the AstraZeneca vaccination.

    Researchers at Moderna in the United States previously stated that the vaccine developed by the company has a protective effect on the mutant strains found in the United Kingdom and South Africa, but the vaccine recipients have a weak immune response to the mutant strains found in South Africa.
    .

    The US biotechnology company Novavax said last month that research shows that the company’s vaccine is 85.
    6% effective against the mutant virus found in the UK, but it is less effective against the mutant virus found in South Africa.
    .

    At present, many pharmaceutical manufacturers have indicated that they will adjust the vaccine, hoping to increase the effectiveness of the mutant virus.

    AstraZeneca has previously stated that it will strive to develop an improved vaccine against the mutant virus found in South Africa before the fall, while Pfizer recently said it will discuss with regulatory agencies whether it needs to develop an "enhanced" vaccine or increase the injection dose.

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