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International war "epidemic" operation
Science and Technology Daily, Beijing, February 9 (Reporter Liu Xia) According to the "New India Express" website reported on the 7th, scientists from India's Kazi Nazrul University and the Indian Institute of Science and Education joined hands to design a new Peptide vaccines
.
They claim that the vaccine can produce protective immunity against all six highly pathogenic members of the coronavirus family and protect against new variants of the coronavirus that may emerge in the future
"In this study, we used an immunoinformatics approach to design 'AbhiSCoVac', a multi-epitope, multi-target chimeric peptide that can Protective immunity against 6 strongly pathogenic members of the coronavirus family, including 2019-nCoV, SARS-CoV and MERS-CoV
.
"
Epitopes exist on the surface of antigens and are chemical groups with special structures that determine the specificity of antigens.
Antigens bind to the corresponding lymphocyte surface antigen receptors through epitopes, thereby activating lymphocytes and causing immune responses
.
"This newly designed vaccine is highly stable, antigenic and immunogenic,
" said the researchers.
Abijian Chowdhury, a researcher at Qazi Nazrul University, told the Press Trust of India that they used computational methods to develop the vaccine
.
It is reported that in the latest study, the researchers first identified the conserved regions of the spike protein of 6 different coronaviruses (the new coronavirus binds to the ACE2 protein on the surface of human cells through its spike protein, enters the cell and causes infection), these regions Few mutations have occurred, so changes have been limited during the pandemic
.
In addition, these regions in the spike protein are highly immunogenic, meaning they can generate high levels of immune memory in the body -- which is integral to fighting off viruses
"Furthermore, unlike other vaccines, these regions of the spike protein were selected after they showed high binding to a protein called TRL4, which is responsible for detecting SARS-CoV-2 in the body and triggering immune response
.
"
The researchers said they injected the vaccine into virtual patients and found that the vaccine protected the recipients well from the virus, and they plan to manufacture the vaccine and conduct further testing
