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    Home > Biochemistry News > Biotechnology News > Induce apoptosis of colon cancer cells and enhance cytoprotective autophagy

    Induce apoptosis of colon cancer cells and enhance cytoprotective autophagy

    • Last Update: 2021-09-04
    • Source: Internet
    • Author: User
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    Image: A single dose (15 mg/kg) of AOM was injected intraperitoneally in mice (the first week), followed by 3 times of 2% DSS in the drinking water every two days (the second week) (the second week)


    " Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells " reported that the 3-2,5 -diphenyltetrazolium bromination test showed that AS has a significant effect on the survival rate of colon cancer cells; SW620, HCT116 and HT29


    Studies have shown that microtubule-associated protein 1A/1b light chain 3B accumulation, isolator 1 activation, autophagy-related 4B cysteine ​​peptidase inactivation, acid vesicle organelle formation, and Beclin-1/Bcl-2 dysregulation revealed as Induced autophagy


    In addition, as induces cytoprotective autophagy and apoptosis through extracellular signal-regulated kinase signaling cascade


    The author said: "Colorectal cancer is the third most deadly cancer in the world, and the fourth most common cancer


    Colon cancer originates from colon epithelial cells, which line the cavities of organs


    Since the lack of apoptosis can lead to the occurrence of cancer, targeting apoptosis is the focus of current cancer treatment


    The main problem of cancer cells is that the cell growth and proliferation are out of control, and they are resistant to apoptosis


    In the absence of apoptosis, autophagy induces a type of cell death, called autophagic cell death, also called type II programmed cell death, which is different from type I programmed cell death, which is apoptosis


    In SW620 cells, AS reduces cell viability by blocking intracellular ROS and blocking ERK and AKT signaling pathways, and induces apoptosis and cytoprotective autophagy


    The Hseu research team concluded in their "American Aging Research Results", "All the results indicate that Salmonella may act as an inducer of cytoprotective autophagy and apoptosis by regulating ROS in colon cancer cells


    DOI-https://doi.


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