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Induction of IL19 expression through JNK and cGAS STING to regulate DNA damage-induced cytokine production

 Last Update: 2021-12-24
 Source: Internet
 Author: User

Stress produces cytokines

DNA damage, such as damage caused by ionizing radiation or inhibition of DNA replication checkpoint kinases, activates the cGAS-STING pathway and the transcription factor NF-κB, thereby triggering the secretion of pro-inflammatory cytokines, such as IL-1, IL-6 and IL- 8

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Here, we demonstrated that the expression of the gene encoding interleukin-19 (IL-19) is enhanced by c-Jun N-terminal kinase (JNK) and cGAS-STING-mediated DNA damageIL19The production of cytokines IL-1, IL-6 and IL-8 requires expression

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