Infected people face a higher risk of depression, the first mRNA vaccine that can be stored at room temperature comes out

The world's first freeze-dried mRNA vaccine comes out, which can be long-term stable at 25°C

The world's first freeze-dried mRNA vaccine comes out, which can be long-term stable at 25°C

Source: bioRxiv

Source: bioRxiv Source: bioRxiv

In a study published on the preprint platform bioRxiv on February 10, a lyophilized lipid nanoparticle (LNP) mRNA SARS-CoV-2 vaccine was developed that can be stored at room temperature (25°C) with long-term stability, and demonstrated Suitability of lyophilization techniques for different mRNA sequences and lipid compositions

The research team has developed freeze-dried mRNA-LNP new crown vaccines against the original strain of the new coronavirus, the delta variant, and the Omicron variant, all of which can induce high levels of IgG titers and antibody neutralization responses

ACE2 may be a key factor in metabolic complications of COVID-19

ACE2 may be a key factor in metabolic complications of COVID-19

Source: Cell Metabolism

Source: Cell Metabolism Source: Cell Metabolism

On February 11, a study published in Cell Metabolism found that down-regulation of the ACE2 pathway is a key mechanism mediating metabolic complications such as diabetes caused by new coronary pneumonia, and identified an agonist of ACE2 enzyme activity for the first time.

Combining the transcriptome changes caused by the new coronavirus infection and the subsequent experimental verification of the expression of downstream genes of ACE2, the researchers finally identified three types of imatinib, methazolamide and harpagoside that may potentially improve the new coronavirus infection.

China conditionally approves Ruihui's new crown drug

China conditionally approves Ruihui's new crown drug

Source: State Drug Administration

Source: State Drug Administration Source: State Drug Administration

On February 12, the State Food and Drug Administration conducted emergency review and approval in accordance with the relevant provisions of the "Drug Administration Law" and in accordance with the special drug approval procedures, and approved Pfizer's new crown virus treatment drug Nematicavir Tablets/Ritonavir Tablets with conditions.

According to the official website of the China Food and Drug Administration, the drug is an oral small molecule new coronavirus treatment drug, which is used to treat adults with mild to moderate new coronavirus pneumonia with high risk factors for progression to severe disease, such as advanced age, chronic kidney disease.

Progesterone makes women less sick with coronavirus

Progesterone makes women less sick with coronavirus

Source: Signal Transduction and Targeted Therapy

Source: Signal Transduction and Targeted Therapy Source: Signal Transduction and Targeted Therapy

On February 14, a study published in Signal Transduction and Targeted Therapy showed that in a hamster model of new coronavirus infection, progesterone has potential use in new crown treatment

It is understood that high endogenous progesterone levels may protect infected women from progressing to severe disease

Good experimental data for mRNA vaccine against Omicron variant

Good experimental data for mRNA vaccine against Omicron variant

Source: Cell Research

Source: Cell Research Source: Cell Research

On February 14, in a study published in "Cell Research" (Cell Research), the world's first mRNA vaccine animal experimental data specific to the Omicron variant was released, indicating that the Omicron specificity The vaccine has considerable protection against the Omicron variant

The research team identified two of the most efficient mRNAs from 18 candidate mRNAs, named Omicron/1 and Omicron/2 respectively.

New coronavirus drug protects hamsters from infection

New coronavirus drug protects hamsters from infection

Source: Nature Communications

Source: Nature Communications Source: Nature Communications

On February 15, a study published in "Nature Communications" showed that the new coronavirus antiviral drug PF-07321332 (PF-332) can protect Syrian hamsters from some "notable variants" of the new coronavirus infection and reduce the risk of virus transmission

The researchers found that Syrian hamsters infected with the beta or delta variants through the nose showed no symptoms and showed no signs of disease after oral administration of PF-332 for four consecutive days

Vaccines have persistent Spike-specific MBC responses

Vaccines have persistent Spike-specific MBC responses

Source: Nature

Source: Nature Source: Nature

On February 15, a study published in Nature tracked memory B cell (MBC) responses in BNT162b2 recipients for up to 6 months and found that vaccine recipients had sustained Spike-specific MBC responses

The study sequenced different B cell subsets in 8 vaccinators, tracked 1540 Spike-specific B cell clones, and found that early blood Spike-specific plasmablasts exhibited the lowest affinity differentiated somatic hypermutation (SHM) maturation frequency

People with Covid-19 face higher risk of depression

People with Covid-19 face higher risk of depression

Source: BMJ

Source: BMJ Source: BMJ

In a paper published in the British Medical Journal (BMJ) on February 16, researchers used statistical modeling to compare the mental health outcomes of infected people with another two groups of uninfected people (concurrent and before the outbreak).

Compared with uninfected people, people with Covid-19 were 60% more likely to experience mental health problems or require related medication in a year overall, equivalent to 64 more people per 1,000 people who needed a mental health diagnosis or prescription

Omicron's new son variant BA.
2 may make the virus last longer

Omicron's new son variant BA.
2 may make the virus last longer

On February 16, Nature News reported that Omicron's sub-variant BA.
2 was spreading rapidly in countries such as Denmark, the Philippines and South Africa in the past few weeks
.
The virus was first detected in Africa in late November and has quickly spread globally
.

Four studies published on the preprinted literature platforms bioRxiv and medRxiv show that BA.
2 is indeed more transmissible than BA.
1, and it is easier to evade immunity from vaccines and previous infections; BA.
2-specific genes lead to antibodies Neutralizing BA.
2 was less effective than neutralizing BA.
1; a study including 8,000 Danish households showed that compared with BA.
1, people who were unvaccinated or only received two shots without a booster shot More susceptible to BA.
2
.

The newly discovered virus has a sequence homology of 96.
8% with the new coronavirus

The newly discovered virus has a sequence homology of 96.
8% with the new coronavirus

Source: Nature

Source: Nature Source: Nature

On February 16, a study published in "Nature" found that the bat coronavirus BANAL-52, which is the closest to the new coronavirus so far, has a sequence homology of 96.
8% with the new coronavirus.
The virus with the highest sequence homology known
.

The receptor binding domain RBM in the RBD of the BANAL family is only 1-2 amino acids different from the new coronavirus RBS.
The binding ability of these viruses to human ACE2 is stronger than the original strain of the new coronavirus
.
It can enter Vero-E6 cells and human cells Caco-2 through ACE2 for replication, and can also be neutralized by 2019-nCoV neutralizing antibodies, further suggesting that the virus and 2019-nCoV have highly homologous antigenic and serological characteristics
.

Vaccination produces antibodies that are more capable of responding to mutant strains than antibodies acquired after infection

Vaccination produces antibodies that are more capable of responding to mutant strains than antibodies acquired after infection

Source: Cell

Source: Cell Source: Cell

On February 16, a study published in Cell found that antibodies produced through vaccination were more effective against new coronavirus variants than antibodies obtained after natural infection
.

Vaccination produces a range of antibodies, the breadth of which allows the immune system to respond to other virus variants, the researchers said
.
Areas in lymph nodes called germinal centers (where the immune system selects and produces antibodies) are highly active in the weeks following vaccination, and in severe cases of COVID-19, the structure and cellular composition of the germinal centers are severely disrupted
.

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