Ingestion: Toxoplasma infection during pregnancy can affect PD-1-Treg cell function and lead to adverse pregnancy outcomes.

Gonorrhea toxoplasma infection during pregnancy can lead to adverse pregnancy outcomes.
previously, we have reported that these results are related to impaired function of membrane-disfilmed Treg cells;
reported that the inhibition of Treg cells depends on the expression of PD-1.
study explores the role of defilmed PD-1-Treg cell function in adverse pregnancy outcomes caused by toxoplasma infection.
toxoplasma-infected pregnant mice at the expense of 14 days of pregnancy to observe their pregnancy outcomes.
used a flow cytometer to determine the expression of PD-1 on decellular Treg cells, as well as on Deocellular PD-1 plus and PD-1-Treg cells in Foxp3, CTLA-4, TGF-β, and IL-10.
results showed that the expression of PD-1 on gonorrhea-infected mice was significantly higher than in normal mice, while the expression of PD-1 in Foxp3, CTLA-4, TGF-β and IL-10 was significantly higher than in normal mice.
same time, Foxp3, CTLA-4, TGF-β, and IL-10 expressed higher expression on shedding PD-1-Treg cells than in infected mice.
the expression of PD1-Treg cells in infected mice was higher than that of PD-1-Treg cells.
, however, there was no significant difference between these expressions on PD-1-Treg cells between infected mice and normal mice.
, the absolute percentage of deocellular PD-1-Treg cells in infected mice decreased significantly compared to normal mice.
above, these results show that toxoplasma infection mainly affects the function of the membrane-defilmed PD-1-Treg cells, which will lead to a micro-environment with insufficient immune tolerance, leading to adverse pregnancy outcomes.
.