Int J Antimicrob Agents: Hydroxychloroquine significantly reduces viral load in COVID-19 patients

Chloroquine and hydroxychloroquine are effective for SARS-CoV-2 and have been reported to be effective in PATIENTS-19 patients in China.
study, which aims to evaluate the effects of hydroxychloroquine on respiratory viral loads, was published online in Int J Antimicrob Agents.
study included patients diagnosed with COVID-19 in France between early March and March 16 receiving 600 mg of hydroxychloroquine per day and testing the viral load in their nasopharyngeal swabs daily in a hospital setting.
based on its clinical manifestations, azithromycin is added to the treatment.
patients from another centre and cases that refused the programme were classified as negative controls.
end of the study was to include the presence and non-existence of the post-Day6-post virus.
the subjects included in the trial, 6 were asymptomatic, 22 had symptoms of upper respiratory tract infections and 8 had symptoms of lower respiratory tract infections.
20 patients were treated in this study, the D6-post was significantly less viral when it was included than in the control group, and the average carrying time was much lower than reported in the literature of untreated patients.
addition of azithromycin to the virus on the basis of hydroxychloroquine significantly improved the efficiency of the removal of the virus.
Despite the small sample size, our study showed that hydroxychloroquine therapy was significantly associated with reduced/disappearing viral load in PATIENT-19 patients, with better results after combining azithromycin.
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