Int Wound J: External Cadexomer Iodine can be used to treat diabetic foot ulcers.

This study compared the effects of local antimicrobial therapy with Cadexomer Iodine for 2 weeks vs. 6 weeks in patients with diabetic foot ulcers (DFU) with chronic biofilm infection, which was published online in Int Wound J.
included non-healing DFU patients with suspected chronic biofilm infection.
were randomly treated with local Cadexomer iodine for 2 or 6 weeks.
biopsies were obtained from ulcers before and after treatment and DNA sequencing and real-time quantitative polymerase chain reactions (PCRs) were performed to determine the total microbial load, community composition and bacterial diversity.
results, the scanning electroscope confirmed that 18 ulcers have biofilms, suspected chronic biofilm infection.
Cadexomer Iodine reduced the microbial load by an average of 0.5 log10 in 14 of the 18 samples (78 percent).
no statistical difference in the total microbial load, regardless of the length of treatment.
6 weeks, there was no difference in healing rates between the two groups.
, the results show that Cadexomer iodine reduces the total microbial load of chronic biofilm infection DFU and affects the composition and diversity of the microbiome.
of all ulcers in both groups had a preliminary reduction in wound size after the application of Cadexomer iodine, which may reflect their effect on the biofilm.
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