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Interferon non-dependent STING signaling pathways promote resistance to HSV-1 in the body.

 Last Update: 2020-08-03
 Source: Internet
 Author: User

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The interferon gene stimulator (Stimulator of Interferon Genes, STING) pathway triggers an effective immune response after DNA is identified.
in order to initiate signal conduction, STING's C-end tail (CTT) serine 365 (S365) is phosphorylation, resulting in the induction of type I interferon (IFNs).
, evolutionaryly conservative reactions such as autophagy also occur in STING's downstream signaling pathways, but scientists still don't yet know their relative importance in in vivo infections.
in general, this study shows that, at least in mice, stinging, which does not rely on interferon, mediates an antiviral response that relies on STING, providing new ideas for revealing the process and mechanism of antiviral response.
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