Intermittent diet loss, fat reduction, liver protection, or rely on gut microorganisms.

Recent achievements in the field of obesity research have left one reader lamenting in a message: "Why do your research always stare at my fat!" And to paste the autumn season, the odd cake is not do not want to have a big quick, but not only to meet the desire of the mouth, but also to achieve a healthy long life, these two joys want to overlap with each other, even if it is not so easy.
the true meaning of weight loss, nothing but has long been said to be extremely skilled in "holding the mouth, open the legs."
, however, how to achieve these two objectives more efficiently has been the subject of much debate, and new ideas and methods have been put forward.
After the 2012 BBC documentary Eating, Eating and Longevity and Light Break Diet, the diet has become a new favorite for weight loss, and the pastry has taken you through a number of related findings before: JAMA: "Simulated Eating Diet" may really turn back the clock and keep us alive longer; this is the godfather of the recently brushed-up "light cut-off therapy"! Singer power.
study of the mechanism of diet loss has also been ongoing.
a collaboration between Hunan Normal University and the National Institutes of Health, published in cell-metabolism, has taken scientists one step closer to solving the puzzle.
The first author of this paper is Associate Professor Li Guolin of Hunan Normal University, chinese and American researchers after a series of explorations and experiments found that the loss of weight, relying on the constant discovery of wonderful function of gut microorganisms! Metabolites secreted by specific gut microorganisms convert white fat cells that store energy into beige fat cells that consume energy for metabolism.
also reduce fat liver caused by obesity and enhance insulin sensitivity! Since it's about losing weight, you have to pull the fat out and criticize it.
Mammals in the main presence of adipose tissue is white fat, brown fat and beige fat three, white fat is mainly responsible for storing excess energy, brown fat is mainly in infestation cold stimulation when metabolic heat production, adulthood gradually disappeared, and the form between the two beige fat and brown fat has similar heat production function, can also promote energy consumption.
Because the amount of brown fat in adults is very small, scientists believe that compared to brown fat, people's body white fat "beige", complete from bad fat oil to good fat gorgeous turn, has a higher practical value, but there is no effective means to achieve this process.
is there a link between weight loss and fat "make-up"? This starts with metabolic changes caused by eating breaks.
The first part of the study, comparing mice that had 15 cycles of intermittent eating (i.e., 24-hour breaks, 24-hour resumed feed supply to a one-cycle MODF group, referred to below as cut-offs) with the same one-month dietary supply without restrictions, found that while there was no difference in overall food intake, the mice in the cut-off group had a lighter weight.
is this the case? Either the metabolic efficiency of converting nutrients from food into weight is low, or the overall energy consumption is high.
further analysis showed that the mice in the break-up group did achieve significant fat reduction, especially the reduction of visceral fat, while the muscle mass did not decrease, meaning that the overall metabolic efficiency did not decrease, the first may be excluded.
go about the high consumption of energy? After analyzing metabolic data, the researchers determined that this energy was consumed by the metabolic heat produced by fat. The
researchers also found that the gene expression of the mediated heat-producing key molecule decoupling protein-1 (Ucp-1) was significantly inhibited in the inter-shoulder fat, which is the main area of brown fat production, meaning that the burned fuel is not the original brown fat.
in the groin area of mice, the researchers finally found the answer -- that the white fat here was beigeed, providing the energy needed for metabolism.
a further short-term break (three cycles), the researchers also determined that fat beigeing was the cause, not the result, of weight loss.
, readers of acute children can't help but ask: What about gut microbes? The title says it came first, where did it go? In previous experiments, the effects of diet loss have been clarified, but the researchers also found that the mechanisms that mediat this process differ from the mechanisms of brown fat heat production revealed in previous studies.
As more and more studies have shown a link between gut microbes and obesity, researchers have also looked at this perspective and found a significant increase in the proportion of thick-walled bacteria in the intestines of mice in the cut-off group compared to the python, which previous studies have shown can lead to increased intake of glucose in white adipose tissue in the groin region, meaning that the consumption of adipose tissue here increases due to beige coloration, which is also in line with previous results from this trial.
to confirm the direct effects of these microbes, the researchers transplanted microbes extracted from the intestines of the cut-off and obese mice into antibiotic-treated mice, and observed similar results to the break-up experiment.
the same effect in treating mice treated with antibiotics, confirming the need for gut microbes to regulate the effects of eating and losing weight.
the researchers analyzed the gut contents of mice with long-term and short-term breaks to determine what substances secreted by gut microbes that really regulate the effects of weight loss.
analysis showed that acetate and lactate showed significant increases in the intestine contents of both groups of mice, which induced the beigeization of white fat.
these findings have formed a clear chain: food loss changes the composition of microorganisms in the gut, which increases the secretion of acetate and lactic acid, makes white fat beige, metabolizes heat production, and achieves fat reduction.
this series of changes, which cannot be observed in mice that emptied gut microbes, but can be achieved by implanting gut microbes in mice that have been cut off.
The researchers switched all of the subjects to obese mice induced by a high-fat diet and then grouped them for a dietary cut-off experiment, and found that the mice in the cut-off group not only lost weight as the cut-off cycle progressed, but also had a higher sensitivity to insulin, and that fatty liver disease caused by obesity was significantly reduced.
Further tests showed that obese mice do not use the diet method, only after antibiotics to remove the original gut microorganisms, transplanted into the gut microorganisms of the eating mice, also got a similar weight loss, fat reduction, liver protection multiple effects, which means that even if not cut-off, simply supplement the intestinal microorganisms of the mice may achieve the same weight loss effect.
this study not only clarifies the mechanism of diet loss regulated by gut microorganisms, but also shows the good effect of break-up on the treatment of obesity-related fatty liver disease, diabetes and other diseases.
Combined with the current research on gut microbes, I believe that this path is not too far away from clinical applications, for a meal like the odd pastry, then it is probably the dream of general happiness time.
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