Intestinal bacteria may contribute to the early diagnosis of Alzheimer's disease

The team of Chen Shengdi, a professor of neurology at Ruijin Hospital affiliated with Shanghai Jiaoba University School of Medicine, has studied the evolution of the intestinal bacteribus for Alzheimer's disease (AD) and mild cognitive impairment (MCI), revealing that intestinal bacteribus detection may contribute to the early diagnosis of Alzheimer's disease. The study was published recently in the international medical journal Alzheimer's disease and dementia.
AD is the most common type of dementia in old age, and its incidence increases year by year. Recent studies have shown that intestinal bacteria are involved in the occurrence and development of AD in a variety of ways. However, there is no clear evidence as to whether laboratory studies can be used in the diagnosis of clinical ADs, especially in MCI, where symptoms are mild at an early stage.
On the basis of the disease sample bank and database established in the early stage, Chen Shengdi team completed the comparative analysis of AD, MCI and normal control of the intestinal bacteria of elderly volunteers through clinical data screening, classification of blood and fecal sample essential control, microbial cluster detection and verification.
found that the diversity of fecal microbiomes in patients with AD was significantly lower than normal, but similar to that of MCI patients. After controlling for a combination of age, sex and constipation, the abundance of 6 genus AD and MCI patients increased and the abundance of 5 genus decreased. Further studies confirmed that there were similar changes in the gut microbiome and AD patients in MCI patients, with an increase in the genus E. coli and Lactobacillus lactic acid, and a decrease in the genus Bacillus acuity.
" study confirmed clinically that intestinal bacteria are indeed involved in the early onset of human AD. Chen said that during the MCI phase before AD, the gut microbiome had changed similarly to that of the AD phase.
The results, on the one hand, contribute to a more accurate and comprehensive understanding of the pathogenesis of AD, provide important evidence and measurable indicators for early diagnosis and intervention in MCI, and, on the other hand, help researchers further study the mechanisms of brain-intestinal interactions to find therapeutic targets for interventions for such neurodegenerative diseases, said Professor Tang Vedong, author of the paper. (Source: Huang Xin, China Science Journal)
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