Inventory: 21 "China class 1" anti-tumor drugs under research in clinical phase III (Part 2)

Source: Yaodu Toutiao 2018-03-22 in the previous "inventory: 21 ongoing" class 1 "anti-tumor drugs in research (Part I)" in clinical phase III, the author summarized 21 "clinical phase III", "ongoing", "class 1" and "anti-tumor drugs", and briefly summarized them In the overview, the main focus is drug registration and acceptance information and some clinical information Due to the long length, the synthesis information of 17 chemicals in 21 drugs cannot be fed with the article, so it is divided into two parts The synthesis information of 17 chemicals is summarized as follows 17 "China class 1" antineoplastic chemicals in clinical phase III Through drug delivery data query: in the current 13215 drug databases (data updated to March 11, 2018), 677 drugs in "clinical phase III" and "ongoing" clinical status in the R & D stage, including 49 drugs belonging to "China class 1"; among them, 21 anti-tumor drugs and 17 chemical drugs, the search results are as follows: (the search results are from the drug ferry data) the 17 "China class 1" anti-tumor chemicals in clinical phase III are sabaficin hydrochloride, enrotinib hydrochloride, famitinib malic acid, MB 07133, dipropionate, floreplatin, vorolanib, donafinib toluenesulfonate, casein, glufosamide Sofantini, paclitaxel, zanubrutinib, voritinib, entenole, eschatinib, alanine britannib, detailed "drug name - target - Indication - R & D code - R & D company", see the following table: the above 17 antitumor drugs in research ~ synthesis information 1 The synthesis route of sabaficin hydrochloride is as follows: 2 The synthesis route of androtinib hydrochloride is as follows: 3 the synthesis route of famotinib malate is as follows: 4 the synthesis route of MB 07133 is as follows: route one route two 5 the synthesis route of two sodium carboprost phosphate is as follows: route one route two routes three routes four Route 5: 6 The synthesis route of fluorapine is as follows: 7 The synthesis route of vorolanib is as follows: 8 The synthesis route of donafinil toluene sulfonate is as follows: Route 1, route 2, route 3, Route 4, route 5; 9 The synthesis route of casein is as follows: 10 The synthesis route of glufosinate amide is as follows: 11 The synthesis route of sofantini is as follows: 12 The synthesis route of paclitaxel is as follows: Paclitaxel is the precursor drug of paclitaxel, and the synthesis information is less, so the synthesis route of extracted paclitaxel is as follows Route 1, route 2, route 3, 13 Bgb-3111 (zanubrutinib) synthesis route is as follows: 14 Voritinib synthesis route is as follows: 15 Entenole synthesis route is as follows: Route 1, route 2, 16 Eisatinib synthesis route is as follows: 17 The route of synthesis of alanine brunib is as follows: Route 1, route 2, route 3, Route 4 (Note: the above 17 chemicals are arranged in no order)