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The
Mycobacterium
genus is comprised of over 30 mdivldual species with a large majority being saphrophytes. However, research on these bacteria has focused primarily on the pathogens
Mycobacterium bow, Mycobacterium tuberculosis
, and
Mycobacterium leprae
, and opportunistic pathogens such as the
Mycobacterium avium
complex and
Mycobacterium kansasil
. These medically important
Mycobacterium
spp. have been studied extensively in terms of antigenicity (
1
,
2
), pathogenicity (
3
,
4
), and physiology (
5
,
6
), and with the development of genetic transformation techniques for mycobacteria (
7
), a new era of dedicated efforts to define these organisms at the genomic level was established Over the past decade, such efforts have been underscored by the isolation of mycobacterial genes encoding immunodommant proteins (
2
,
8
–
10
), virulence factors (
11
–
13
) and the biosynthesis of secondary products (
14
,
15
); as well as the establishment of genome sequencing projects for
M leprae
and
M. tuberculosis
(
16
,
17
). Essential to these accomplishments was the development of efficient means to isolate high quality mycobacterial genomic
DNA
.
