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Original title: Food supplements have been found to be effective in preventing epilepsy
epilepsy is a seizure disorder associated with excessive excitability of neurons in the brain. Unfortunately, there are currently very limited treatment and prevention methods for the disease. However, researchers at the University of Alabama at Birmingham found that induced biopics that alter brain proteins by dietary amino glucose can quickly suppress this pathological neuron hyper-excited state.
these results represent a potential new therapeutic target for epilepsy and suggest that they need to better understand these neural circuit changes and brain physiology.
proteins are the center of life cells, and their activities are tightly and quickly responsive to changing conditions. Adding or removing a phosphoric acid group of proteins is a well-known regulatory protein, and it is estimated that human proteins may have phosphate up to 230,000 bits.
little-known rule comes from the addition or removal of N-acetaminophen glucose proteins, which are usually the main fuel for glucose and neurons. A few years ago, neuroscientist Dr. Lori McMahon and others discovered the second-highest amount of protein in brain cells: O-GlcNAcylation.
, few people knew that O-Glc NAcylation might affect brain function, so McMahon and others decided to do the research. In 2014, they found that the protein's fast O-GlcNAcylation causes long-term activity inhibition of neuron synapses in the hema region (the strength of synapses decreases). The study is the first to find a direct change in the brain's synhap function from rapid changes in the neuron protein O-GlcNAcylation.
because neuro-excited sea horses are an important feature of seizures and seizures, they hypothesized that acute increased protein O-GlcNAc glycosylation may inhibit the pathology associated with these brain diseases.
results were published in the latest issue of Journal of Neuroscience under the title "Acute increases in protein O-GlcNAcylation dampen epiptiform activity in hippocampus".
Our findings support the conclusion that protein O-GlcNAc glycosylation is a neuron excitatory regulator that represents a promising goal for further research into the treatment of epilepsy," they wrote in a statement. The researchers warn that potential inhibition mechanisms can be complex. (Yang Liping)