It was found that metabolic therapy was helpful for the treatment of severe intestinal C.difficile infection in mice

Clostridium difficile (C difficile) is a kind of fatal intestinal infection pathogen, which can cause severe diarrhea, abdominal pain and other symptoms Every year, 500000 people in the United States, mainly the elderly, are infected with the pathogen Recently, researchers from UCLA have found that a class of metabolic therapies can help treat severe intestinal C difficile infection in mice In this study, mice were first inoculated with Clostridium difficile and treated with a drug called csa13 (http:// Using drugs can improve the expression level of four protective metabolites, which can help maintain cell survival The results showed that compared with the control group, the survival rate of the mice treated with drugs was significantly higher, and the weight loss was also significantly reduced At the same time, the recurrence rate of infection was also significantly reduced The results show that fecal transplantation can cure 90% of C difficile infection, but the treatment has not been approved by FDA (http:// and it is very expensive and has serious negative effects In this study, mice were treated with csa13 orally or by injection, while another group received vancomycin After 20 days of treatment and observation, the author found that the expression of four kinds of metabolites in mice treated with csa13 was significantly increased, and these four kinds of metabolites can inhibit infection, reduce the mortality rate and the trend of weight loss The results indicate that metabolic therapy may be able to be used for the treatment of human C difficile infection.