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Image: Antibody-guided Nanoparticle Delivery System
Source: Baylor College of Medicine
Studies have shown that some nucleic acids, such as messenger RNA (mRNA), DNA and related molecules, can effectively treat diseases in a laboratory environment.
"Currently, some TNAs have been approved for clinical use, and clinical trials are ongoing," said Changyi Johnny Chen, Ph.
When naked nucleic acids enter the human body, they encounter some obstacles that limit their availability
Although these obstacles limit their applications, TNAs are a promising method for the treatment of various diseases
Liposomes are one of the most widely used delivery systems.
LGA-PEI nanoparticles
Since they moved to Baylor in 2002, the laboratory of Dr.
Chen said: "Our previous research has shown that certain RNAs, such as microRNA-198 (miR-198), a natural tumor suppressor, may have clinical applications in cancer
"For many years, my laboratory has been developing the TNA delivery system," Chen said
The LGA-PEI polymer spontaneously forms nanoparticles, and the nanoparticle layer is wrapped with TNAs (such as miR-198) to protect them from enzymatic hydrolysis and enhance cellular uptake
"Our results are encouraging, but we still want to further improve our delivery system," Chen said
Antibodies improve delivery
Antibodies are proteins produced by the immune system that can recognize and bind to specific markers on the cell surface
For example, Chen and other researchers previously discovered that mesothelin (MSLN) is abundantly expressed in some human cancers, including pancreatic cancer
"In the current study, we have successfully linked fragment antibodies against MSLN to our LGA-PEI polymer, and used fluorescent tags to show improved MSLN targeted metastasis in pancreatic cancer cells grown in laboratories and animal models.
The Chen laboratory is interested in conducting research to test that this active targeted drug delivery system can inhibit tumor growth and metastasis and improve the overall survival of tumor-bearing animals compared with passive targeted drug delivery or other non-targeted drug delivery systems.
The improved nanoparticle delivery system is a technology platform that can be extended to other types of cancer or diseases to develop new treatment methods, molecular diagnostic strategies or vaccines
DOI
10.
3390 / ph14090841
