J Cereb Blood Flow Metab: Stroke-induced immunosuppression and dysphagia are independently associated with stroke-related pneumonia.

Stroke-related pneumonia is a common complication after stroke and is associated with adverse outcomes.
dysphagia is a known risk factor for stroke-related pneumonia, but the available evidence suggests that stroke-induced immunosuppressive status increases susceptibility to stroke-related pneumonia.
study aims to confirm that stroke-induced immunosuppressive syndrome and stroke-related pneumonia are independent of dysphagia by studying the predictive properties of single-cell HLA-DR expression as a marker of immunosuppressive and biomarkers of inflammation (leukocyte interlecostin-6) and infection (lipopolyglyginbinding protein).
a forward-looking multi-center study design edited at 11 sites in Germany and Spain, including 486 acute ischemic stroke patients.
daily screening for stroke-related pneumonia, dysphagia and biomarkers.
results showed that stroke-related pneumonia was 5.2% frequent.
in multivariate regression analysis, difficulty swallowing and decreased HLA-DR of mononucleocytes were independent predictors of stroke-related pneumonia. The proportion of
pneumonia was between 0.9% of the higher stats of HLA-DR in mononucleosome cells (?21,876 mAb/cell) and 8.5% of the lower quartile (?12,369 mAb/cell).
the proportion of pneumonia increased to 5.9 per cent and 18.8 per cent, respectively, in cases of dysphagia.
patients with no difficulty swallowing and single-cellHLA-DR expression with outright risk of stroke-related pneumonia.
, the results of the study surfaced that dysphagia and stroke-induced immunosuppressive syndrome were independent risk factors for stroke-related pneumonia.
screening for immunosuppression and dysphagia may help identify high-risk patients with stroke-related pneumonia.
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