Sleep is one of the most important physiological aspects of human health.
It helps energy circulation, vitality and rejuvenation.
Insomnia has become the most common sleep disorder, with a high incidence, which seriously affects the quality of life and cognitive function of patients.
Ashwagandha has long been known for its sleep-inducing effects and can be used as an alternative treatment for insomnia.
Recently, a randomized, parallel group, stratified design, placebo-controlled study evaluated the pharmacological effects of Ashwagandha root extract on sleep in healthy subjects and insomnia subjects, and found that Ashwagandha root extract can improve sleep quality and help For the management of insomnia, the results have been published in J Ethnopharmacol.
A total of 80 eligible participants were included in the study, including 40 Arm-A (healthy) and 40 Arm-B (insomnia) subjects.
Randomized: Ashwagandha or placebo for 8 weeks.
The assessment is based on sleep parameters (sleep onset latency, total sleep time, waking up after sleep onset, total time in bed, and sleep efficiency), Pittsburgh Sleep Quality Index and Hamilton Anxiety Scale-A Questionnaire, wake-up alertness assessment and sleep quality Questionnaire.
In addition, the researchers also assessed the safety and adverse events of the treatment and the accompanying medications.
The results showed that in healthy and insomnia subjects, the sleep parameters of subjects in the Ashwagandha group were significantly improved.
The improvement of insomnia subjects was more significant than that of healthy subjects.
ANOVA analysis confirmed that SOL (p 0.
013), HAM-A results (p <0.
05), mental alertness (p 0.
01) and sleep quality (p <0.
05) of patients with insomnia were significantly improved.
The results of two-way analysis of variance confirmed that sleep initiation latency (p<0.
0001) and sleep efficiency (p<0.
0001) improved the most significantly, followed by TST (p<0.
002) and WASO (p<0.
All parameters of the two groups (SOL, TST, WASO, TIB, SE, PSQI, HAM-A, mental alertness and sleep quality) were significantly improved.
Except for the HAM-A and mental alertness scores of the healthy subjects, the changes of each parameter at the end of the study were statistically significant (P <0.
In summary, this study confirmed that Ashwagandha root extract can improve sleep quality and help manage insomnia.
Ashwagandha root extract was well tolerated, and none of the subjects had obvious adverse reactions.
More clinical trials are needed to make the results universal.
Deepak Langade, Vaishali Thakare, et al.
gov/32818573/" target="_blank" rel="noopener">Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study .
2021 Jan 10;264:113276.
gov/32818573/" target="_blank" rel="noopener">Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study
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