J. Exp. Med: Vitamin B12 synergizes the function of ileal epithelial cells and gut microbiota against Salmonella infection

Micronutrients control cellular molecular dynamics, microbial structure and associated metabolism to calibrate gut homeostasis and human health

This vitamin consists of a central cobalt atom attached to the Corin ring of the lower axial ligand 5,6-dimethylbenzimidazole, which is essential for VB12 binding to endogenous factor (IF)

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Recently, researchers from the University of Texas School of Health published an article titled "Vitamin B12 coordinates ileal epithelial cell and microbiota functions to resist Salmonella infection in mice" in the journal J.

Here, VB12 deficiency impairs transcriptional and metabolic programming of IECS and reduces epithelial mitochondrial respiration and carnitine shuttling during intestinal Salmonella typhimurium (STM) infection

Streptomycin treatment depleted SCFA-producing microorganisms and reduced VB12-dependent STM protection

A conceptual model of VB12-dependent mitochondrial regulation in IECS and its impact on STM colonization resistance

Image credit: https://doi.

Taken together, the present findings support a new prospective model by which VB12 coordinates epithelial and microbial responses to intestinal STM infection

references

Yong Ge et al.