J Neurochem: Cerebral blood flow connectivity can be used as a prognostic biomarker for subcortical stroke imaging

Stroke is the main cause of vascular cognitive impairment, such as memory impairment.

Stroke blood vessel

The study used the Rey Auditory and Speech Learning Test (RAVLT) to score patients' episodic memory function.

This study uses voxel cerebral blood flow (CBF) and functional covariance network (FCN) methods to explore the neural basis of verbal memory impairment in patients with subcortical stroke.

CBF Different Brain Regions in Stroke Patients and Normal Controls

Stroke patients and normal controls CBF difference brain stroke patients and controls CBF difference brain

This study found that in patients with subcortical stroke , the CBF of the affected insular cortex, central cap, IFG , STG and central anterior gyrus decreased.

Stroke patients with ipsilateral insular cortex, the central cover, subcortical stroke patients under the cortex ipsilateral insular cortex, the central cover, IFG IFG , , STG STG front and center back and center-back before the CBF CBF decreases.

Compared with NCs , stroke patients exhibit short-term verbal memory (VSTM) deficits.

Compared with NCs and NCs , stroke patients exhibit short-term verbal memory compared to stroke patients who exhibit short-term verbal memory (VSTM) (VSTM) deficits.

Correlation analysis of VLTM and VSTM scores in stroke patients

Stroke patients VLTM and VSTM correlation analysis points stroke patients VLTM and VSTM points correlation analysis

Correlation analysis of CBF value and VSTM score between stroke patients and normal controls

Stroke patients and normal controls CBF values and VSTM correlation points of stroke patients and controls CBF values and VSTM partial correlation analysis

In summary, this study identified multiple changes in the CBF connectivity of the cortex and subcortical areas, which may indicate that the changes caused by subcortical stroke may exist outside the motor system and manifest as the participation of the cognitive function system.

The changes caused by subcortical stroke may exist outside the motor system and manifest as the participation of the cognitive function system.

wiley.

wiley.
com/doi/epdf/10.
1111/jnc.
15359" target="_blank" rel="noopener">Wang, Caihong et al.
“Validation of Cerebral Blood Flow Connectivity as Imaging Prognostic Biomarker on Subcortical Stroke.
”  Journal of neurochemistry, 10.
1111/jnc.
15359.
28 Mar.
2021, doi:10.
1111/jnc.
15359 Wang, Caihong et al.
"Validation of Cerebral Blood Flow Connectivity as Imaging Prognostic Biomarker on Subcortical Stroke.
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