J Oral Facial Pain Headache: Assessment of body function, pain and discomfort in three trigeminal nerve damage replacement models

The purpose of this study was to assess pain and/or inpleasure and physical sensation strain caused by two experimental models of trigeminal nerve damage in healthy participants (local use of capsaicin and local anaesthetic)the double-blind, randomized, placebo-controlled, cross-study included 20 healthy adult participants who were tested in three coursesIn each course of treatment, psychophysical quantitative sensory testing (QST) and electrophysiologically induced trigeminal trigeminal 'pain-specific' blink reflex (nBR) were conducted at the baselineRecord the maximum numerical scoring table pain and unpleasantness scores after 15 minutes after localapplication of 0.1% capsaicin, 5% EMLA, or Vaseline (placebo) preparationsIn addition, qualitative sensor tests and body maps were carried outRepeat the QST and nBR surveys immediately after each applicationThe data uses double-measured variance analysisresults showed that the application of capsaicin was associated with a significantly higher pain and displeasure score (P .001) compared to EMLA and Vaseline, and that the two-way body perception changed differently among the participants and significantly lost thermal function (P030)The application of EMLA induced loss of thermal and mechanical body function (P030), and in the nBR survey, the electroinduced pain score was significantly reduced (PAfter any application, there was no significant change in the electrophysiological composition of nBR (P, the results show that the application of external capsaicin and EMLA mimics certain aspects of body sensitivity changes seen in patients with trigeminal nerve damage and can be used as substitute models for such changes