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Herpes simplex virus type 1 (HSV-1) is probably the most common orofacial pathogen, infecting 3.
We investigated HSV-1 levels in subgingival plaque/gum crevicular fluid and periodontal conditions through PubMed, Scopus, Web of Science, and Google Scholar's MEDLINE searches for case-control and cross-sectional studies
As a result, a total of 12 studies (738 cases, 551 controls) were included in this meta-analysis
Taken together, the results of this study suggest that HSV-1 in subgingival plaque/gingival crevicular fluid is associated with acute onset of periodontitis, but data regarding gingivitis are inconclusive
Original source:
Paolo G Arduino, et al.
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