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Recently, an Australian study was published in the Journal of Thoracic Oncology, mainly based on a large cohort study of the Australian population, to evaluate the impact of gender differences on prognosis in lung cancer patients
.
.
This is mainly based on a large cohort study in the Australian population to assess the impact of gender differences on prognosis in lung cancer patients
The study included lung cancer patients in the 45 and Up study (2006-2009) and followed up until December 2015
.
The study explores prognostic factors and divides them into males and females for stratified analysis of their impact on prognosis
The study included lung cancer patients in the 45 and Up study (2006-2009) and followed up until December 2015
Of the 267,153 participants in the 45 and Up study, 1,130 eligible participants were diagnosed with lung cancer during follow-up (488 women and 642 men)
The median OS of female patients was 1.
When subgroup analyses were performed based on major prognostic factors, including histological subtype, stage at diagnosis, treatment received, and smoking status, women survived longer than men
.
Regardless of smoking status, women with adenocarcinoma had a better prognosis than men with adenocarcinoma (logrank p=0.
When subgroup analyses were performed based on major prognostic factors, including histological subtype, stage at diagnosis, treatment received, and smoking status, women survived longer than men
In univariate regression analysis, men had a significantly higher risk of lung cancer death than women (HR 1.
43, 95% CI 1.
25-1.
64; p<0.
0001)
.
After minimal adjustment (age and year at diagnosis), the additional risk of death was reduced by 33% (HR 1.
In univariate regression analysis, men had a significantly higher risk of lung cancer death than women (HR 1.
Taken together, the study shows that sex-related differences in lung cancer survival are largely determined by known prognostic factors, suggesting an opportunity to explore sex differences in treatment preference, choice, and access
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Taken together, our findings suggest that sex-related differences in lung cancer survival are largely determined by known prognostic factors, suggesting an opportunity to explore sex differences in treatment preference, choice, and access
Original source:
Original source:Yu XQ, Yap ML, Cheng ES, Ngo PJ, Vaneckova P, Karikios D, Canfell K, Weber MF.
Yu XQ, Yap ML, Cheng ES, Ngo PJ, Vaneckova P, Karikios D, Canfell K, Weber MF.
Evaluating prognostic factors for sex differences in lung cancer survival: findings from a large Australian cohort.
J Thorac Oncol.
2022 Feb 3: S1556-0864(22)00085-5.
doi: 10.
1016/j.
jtho.
2022.
01.
016.
Epub ahead of print.
PMID: 35124253.
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