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J Urol: Among high-risk and very high-risk prostate cancer patients, which of radical prostatectomy or radiation therapy has a higher survival rate?

 Last Update: 2021-11-02
 Source: Internet
 Author: User

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According to the definition of the National Comprehensive Cancer Network (NCCN), 17% to 31% of newly diagnosed clinically localized prostate cancers are classified as high-risk (Gleason 8-10, or PSA>20 ng/ml, or clinical stage ≥T3)

diagnosis

It is worth noting that when using the JH criteria, compared with HR patients, VHR patients tend to show worse oncology results (biochemical recurrence, metastasis-free survival, and cancer-specific mortality)

When using JH standard, compared with HR patient, VHR patients significantly often exhibit oncology results worse when using JH standard, compared with HR patient, VHR patients significantly often exhibit oncology results worse it is not large Large-scale , population-based analysis to investigate which treatments have advantages in cancer-specific mortality (CSM), especially in JH HR or VHR patients, there is currently no large-scale population-based analysis to investigate which The treatment has advantages in cancer-specific mortality (CSM), especially in JH HR or VHR patients

Recently, researchers from Italy published an article in "J Urol".

They compared radical prostatectomy (RP) with external radiotherapy in the National Comprehensive Cancer Network (NCCN) high-risk (HR) patients and the Johns Hopkins University (JH) high-risk (HR) and very high-risk (VHR) subgroups (EBRT) Cancer-Specific Mortality (CSM) Status They are in the National Comprehensive Cancer Network (NCCN) high-risk (HR) patients and the Johns Hopkins University (JH) high-risk (HR) and very high-risk (VHR) subgroups In, compares the cancer-specific mortality (CSM) of radical prostatectomy (RP) and external radiotherapy (EBRT)

In the surveillance, epidemiology, and final results database (2010-2016), the researchers identified 24,407 NCCN HR patients, of which 10,300 (42%) and 14,107 (58%) were eligible for JH HR and VHR, respectively Standard

CSM of RP and EBRT in patients with NCCN high-risk prostate cancer

The results showed that in the combined NCCN HR cohort, the 5-year CSM rate for RP was 2.

CSM of RP and EBRT in the subgroup of JH extremely high-risk prostate patients

In summary, the research data shows that in the combined NCCN HR cohort and in its JH VHR patient subgroup, CSM of RP has an advantage over EBRT

In the combined NCCN HR cohort and in the subgroup of JH VHR patients, the CSM of RP has an advantage over EBRT.

Original source:

Francesco Chierigo, Mike Wenzel, Christoph Würnschimmel et al.

Survival after Radical Prostatectomy vs.

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