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Hematuria is a common clinical manifestation of urothelial carcinoma (UC) and the main symptom of UC
.
The American Urological Association (AUA) guidelines recommend clinical examination of patients with hematuria, but only 0.
The American Urological Association (AUA) guidelines recommend clinical examination of patients with hematuria, but only 0.
The Cxbladder (Cxb) test combines genomic biomarkers in urine with phenotype and clinical data, and can classify hematuria patients as low-probability or high-probability patients with urothelial cancer (UC)
.
Cxbladder Resolve (CxbR) is used after Cxb Triage (CxbT) and Detect (CxbD) to identify patients with high probability of UC tumors
The researchers verified the diagnostic performance of CxbR in identifying high-grade tumors (HIT) , and verified the algorithm of Cxb detection to distinguish high-grade and low-grade tumors.
CxbR was developed in three studies in the United States, Australia, and New Zealand, and a total of 863 hematuria patients were enrolled
.
In a prospective observational study in the United States, researchers verified CxbR in 548 hematuria patients and also verified the effect of combining CxbR with other Cxb tests
In the development data set, the sensitivity of CxbR to recognize HIT was 92.
4% (95% CI 83.
3-96.
7), and the specificity was 93.
8% (95% CI 86.
8-97.
2)
.
In external verification, the Cxb test correctly avoided further testing in 87.
CxbR diagnostic performance characteristics
CxbR diagnostic performance characteristicsIn summary, CxbR has high sensitivity and specificity, and can correctly identify all HITs
.
The Cxb test can accurately distinguish patients with low/high probability of HIT, and its diagnosis rate is 4.
CxbR has high sensitivity and specificity, can correctly identify all HIT CxbR has high sensitivity and specificity, can correctly identify all HIT
Original source:
Original source:Jay D Raman, Laimonis Kavalieris, Badrinath Konety et al.
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