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Recently, the heart blood vessels published on the prestigious journal JAHA the areas of disease research article, the study was designed to investigate the clinical significance of acute intracerebral hemorrhage (ICH) first 24 hours of heart rate (HR) and heart rate variability (HRV), and how Lead to worse clinical outcomes
.
In the ATACH-2 (Intracerebral Hemorrhage Antihypertensive Treatment 2) trial, HR was recorded every 15 minutes and every hour from baseline to 1 hour during the first 24 hours after randomization
.
The researchers calculated the following: average, standard deviation, coefficient of variation, continuous variation, and average actual variation (ARV)
Of the 1000 subjects in the ATACH-2 trial, 994 subjects with available HR data were included in the analysis
.
Overall, 262 patients had enlarged hematomas, and 362 patients had adverse outcomes
Association between average heart rate (HR) and poor functional outcomes
The increase in mean HR was linearly correlated with adverse outcomes (adjusted odds ratio [aOR] for every 10 bpm increase was 1.
31, 95% CI was 1.
14-1.
50), but it was not related to hematoma enlargement, while HR-ARV was correlated with hematoma enlargement (aOR was 1.
06, 95 %CI is 1.
01-1.
12) and unfavorable outcome (aOR is 1.
07, 95%CI is 1.
01-1.
3)
.
For every 10 bpm increase in average HR, the probability of adverse outcomes increased by 4.
The increase in mean HR and HR-ARV within the first 24 hours of acute ICH was independently associated with adverse outcomes
Original source:
Kaori Miwa.
et al.
Effect of Heart Rate Variabilities on Outcome After Acute Intracerebral Hemorrhage: A Post Hoc Analysis of ATACH-2 .
JAHA.
2021.
