JAHA: The relationship between white matter structure and amyloid deposition

White matter abnormality is a common feature of aging and Alzheimer's disease, and it is often more serious in blacks

Recently, the heart blood vessels published on the prestigious journal JAHA the areas of disease research article, this cross-sectional study aimed to assess the association between community sample of older people without dementia abnormal white matter and cortical amyloid, and to assess the people Kind of regulation effect

Participants in the Community Atherosclerosis Risk-Positron Emission Tomography (ARIC-PET) study underwent brain magnetic resonance imaging and used diffusion tensor imaging to quantify the white matter hyperintensity volume and microstructure integrity

In 322 participants (43% blacks), after adjusting for demographics and cardiovascular risk, every SD increase in white matter hyperintensity volume was associated with a greater probability of increased amyloid (odds ratio [OR ] Is 1.

The results of this study show that in elderly people without dementia, there is a moderately positive correlation between high white matter signal and elevated amyloid

Keenan A.