JAHA: The significance of the strengthening of the intracranial aneurysm wall without rupture

Unbromed aneurysm wall enhancement (AWE) on an aneurysm wall scan image may be an effective way to predict the tendency of a brain aneurysm to rupture.
, however, the pathophysiological mechanism of AWE is not yet clear.
recently published a study in JAHA, an authoritative journal in the field of cardiovascular disease, to assess the relationship between AWE and tissue pathological changes.
the study included 35 patients with 41 unbromed intracranial aneurysms who underwent surgical clamping.
researchers conducted histological assessments of 27 aneurysms.
researchers assessed the macro and micro characteristics of unbromed intracranial aneurysms that were associated with or not enhanced.
under the microscope include inflammatory cell invasion and vascular dilation, chemical staining of CD68, CD3, CD20 and myelin peroxidase through immunotiserials.
the study, 21 (51.2%) aneurysms showed AWE (partial AWE, n=7; circular AWE, n=14).
atherosclerosis and translucent aneurysms were 17 and 14 respectively.
single-variable analysis found that aneurysm size, irregular, atherosclerosis, and translucent aneurysms were associated with AWE (P<0.05).
multi-factor regression analysis showed that atherosclerosis was the only factor significantly and independently associated with AWE (P=0.027).
examination found that inflammatory cell immersion, in-cavity thrombosis, and vascular dilation were significantly associated with AWE (P<0.05).
Thus, although AWE may be associated with atherosclerosis lesions of unbromed intracranial aneurysms on vascular wall magnetic resonance imaging scans, inflammatory cell immersion of atherosclerosis, intracranial thrombosis, and vascular dilation may be the main pathological characteristics associated with AWE.
, however, the underlying pathological mechanisms of AWE still need further study.