JAMA: 1/7 adults get sick, not just headaches!

Migraine is a chronic and intermittent primary headache disease characterized by moderate to severe pain and specific related characteristics, including nausea/vomiting, photophobia, and phonophobia
.

Approximately one-third of migraine sufferers have aura symptoms, which are transient neurological symptoms (the most common being visual disturbances) before the onset of headaches caused by changes in brain activity

Approximately one-third of migraine sufferers have aura symptoms, which are transient neurological symptoms (the most common being visual disturbances) before the onset of headaches caused by changes in brain activity

Vascular migraine, especially migraine with aura, is also related to other vascular risk factors, such as high blood pressure, smoking, blood lipid levels, and body composition

To compare the adjusted incidence of CVD among women with migraine aura, women without migraine aura or migraine, and women with other major vascular risk factors, from the Department of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, USA The experts of the company have carried out relevant research, and the results were published on JAMA in the Journal of the American Medical Association
.

Prevent JAMA

The researchers included American female health professionals (Women Health Research Cohort) without cardiovascular disease, and blood lipid measurements were performed at baseline (1992-1995), and they were followed up until December 31, 2018
.

The exposure factor was self-reported migraine with aura

Cardiovascular myocardial infarction

The study population included 27,858 women (mean age at baseline was 54.
7 [7.
1] years), of which 1,435 (5.
2%) had migraine with aura, and 26,423 (94.
8%) had migraine without aura (one year before baseline) 2177 people [7.
8%] had no migraine with aura, 24246 people [87.
0%] had no migraine)
.

During an average follow-up period of 22.

Combining all vascular risk factors, except for the family history of premature myocardial infarction, the incidence of major CVD increased from 39.
55 cases per 1,000 person-years to 62.
96 cases per 1,000 person-years when migraine with aura was added
.

Combining all vascular risk factors, except for the family history of premature myocardial infarction, the incidence of major CVD increased from 39.
55 cases per 1,000 person-years to 62.
96 cases per 1,000 person-years when migraine with aura was added
.

Combining all vascular risk factors, except for the family history of premature myocardial infarction, when migraine with aura is added, the incidence of major CVD increased from 39.

According to vascular risk factors, the incidence of CVD per 1,000 person-years: a correlation study of migraine with aura and the incidence of CVD (N = 27858)

According to vascular risk factors, the incidence of CVD per 1,000 person-years: a correlation study of migraine with aura and the incidence of CVD (N = 27858)

The results showed that the main CVD incidence rate of women with migraine with aura was 3.
36/1000 person-years (95%CI: 2.
72-3.
99), while the incidence of women without aura or migraine was 2.
11/1000 person-years (95%CI: 1.
98- 2.
24)
.

At the same time, the risk of CVD in women with migraine

The risk of CVD in women with migraine with aura is 129%, 167%, and 163% higher than women with obesity, high triglycerides, and low HDL cholesterol , respectively (HR=2.

Corrected incidence of major CVD events per 1,000 person-years in the study of the correlation between migraine with aura and CVD incidence in women

Corrected incidence of major CVD events per 1,000 person-years in the study of the correlation between migraine with aura and CVD incidence in women

Further analysis showed that the incidence of women with diabetes (HR=5.
76, 95%CI: 4.
68-6.
84) or current smoking (HR=4.
29, 95%CI: 3.
79-4.
79]) was significantly higher than that of migraine with aura Women
.

The increase in the incidence of migraine with aura ranges from an increase of 1.

The incidence of women with diabetes (HR=5.

In summary, in this study of female health professionals who were at least 45 years old, compared with women with migraine without aura or migraine without aura, women with migraine with aura had higher cardiovascular Disease adjusted morbidity
.
In summary, in this study of female health professionals who were at least 45 years old, compared with women with migraine without aura or migraine without aura, women with migraine with aura had higher cardiovascular Disease adjusted morbidity
.

 

 

references:

Association of Migraine With Aura and Other Risk Factors With Incident Cardiovascular Disease in Women.
JAMA.
2020 Jun 9;323(22):2281-2289.
doi: 10.
1001/jama.
2020.
7172.

Association of Migraine With Aura and Other Risk Factors With Incident Cardiovascular Disease in Women.
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